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发明公开
CN108473540A 突变的HEV多肽及其用于测定抗HEV抗体的用途 有权

突变的HEV多肽及其用于测定抗HEV抗体的用途
摘要：
本发明涉及戊型肝炎病毒p-ORF2蛋白的多肽，其包含至少氨基酸序列394-660(相对于660个氨基酸的p-ORF2蛋白编号)，其中位置627、630和638的三个半胱氨酸已经被突变，或对于不同长度的p-ORF2蛋白，至少对应于660个氨基酸的p-ORF2蛋白的氨基酸394-660的氨基酸序列，其中位于对应于660个氨基酸的p-ORF2蛋白的位置627、630和638的三个位置的三个半胱氨酸已被突变。本发明还涉及使用这些多肽测定针对p-ORF2蛋白的体液应答的存在或抗体效价的方法，还涉及其在感染戊型肝炎病毒的情况中的用途。无附图。
摘要（英）：

The present invention relates to polypeptides of the ORF2 protein of the hepatitis E virus including at least the amino acid sequence 394-660, numbered in relation to an ORF2 protein of 660 amino acids, in which three cysteines at positions 627, 630 and 638 have been mutated or, for an ORF2 protein of different length, at least the amino acid sequence corresponding to amino acids 394-660 of the ORF2 protein of 660 amino acids, in which the three cysteines located at the three positions corresponding to positions 627, 630 and 638 of the ORF2 protein of 660 amino acids have been mutated. The invention also relates to methods for determining the presence of the humoral response or the number of antibodies directed against the ORF2 protein using these polypeptides, as well as the use thereof in the context of infection with the hepatitis E virus. No figure

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