The invention relates to a 5-series aluminum alloy panel, as well as a preparation method and application thereof. The preparation method of the 5-series aluminum alloy panel is characterized by forced cooling a hot-rolled aluminum alloy panel to be below 200 DEG C at the cooling speed being 15 to 25 DEG C/s. By adopting the cooling method provided by the invention, a fine-grain panel with the grain size being smaller than 30mum can be prepared, so that the strength and the extensibility of the 5XXX-series, particularly 5083 aluminum alloy panel material are improved.