The invention relates to a high-voltage and high-power electric steering gear drive system based on IGBT, belonging to the field of electric drive and solving the problem that the high-power electricsteering gear drive system in prior art has weak overload capability, poor reliability or electromagnetic interference, and occupies controller resources, comprising: a power supply module, a controlsignal isolation module, a Hall signal interface module, a commutation logic generation module, a dead zone module, a drive signal amplification isolation module, a buffer circuit module, a bus voltage detection module, and a drive current detection module. Only a path of PWM signal for controlling the magnitude of the rotating speed and a path of direction control signal for controlling the direction of the rotating speed are needed, and the internal logic generating circuit generates the required six-path switching logic signal, thereby realizing the on-ball application of the high-voltage high-power electric steering gear, and having high integration, high efficiency, high reliability and short-time high-overload capability. The invention has the advantages of strong anti-interference ability, good electromagnetic compatibility and strong short-time high-overload capability, which is conducive to improving the technical index of the whole bomb.