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发明公开
CN108676095A 一种重组免疫毒素及其制备方法和应用 审中-实审

一种重组免疫毒素及其制备方法和应用
摘要：
本发明为一种重组免疫毒素及其制备方法和应用，所述的重组免疫毒素为毒性分子和载体分子的融合蛋白，所述的毒性分子为南瓜蛋白或南瓜蛋白的突变体。其中，所述的重组免疫毒素是通过基因工程方法将南瓜蛋白或南瓜蛋白突变体基因与能结合靶细胞(包括肿瘤细胞和病原细胞等)的抗体或细胞因子基因连接而表达出的融合蛋白；并对重组免疫毒素在抗肿瘤活性、治疗器官移植后的排斥反应或自身免疫性疾病、治疗病原体引起的感染性疾病等可能的适应证中的抗肿瘤活性进行了测试，重组免疫毒素优于毒性分子和载体分子。
摘要（英）：

The invention relates to a recombinant immunotoxin and a preparation method and application thereof, the recombinant immunotoxin is a fusion protein of a toxic molecule and a carrier molecule, the toxic molecule is pumpkin protein or a pumpkin protein mutant, the recombinant immunotoxin is the fusion protein expressed by connection of the pumpkin protein or a pumpkin protein mutant gene with an antibody or a cytokine gene capable of binding to target cells (including tumor cells, pathogenic cells, and the like), the anti-tumor activity of the recombinant immunotoxin and the anti-tumor activityof the recombinant immunotoxin in treatment of rejection reaction after organ transplant, autoimmune diseases, and possible indications such as infectious diseases caused by pathogens are tested to prove that the recombinant immunotoxin is superior to the toxic molecule and the carrier molecule.

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