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发明公开
CN108753626A 一株生物合成16β-羟基-19-去甲-4-雄烯二酮的菌株及其应用 有权

一株生物合成16β-羟基-19-去甲-4-雄烯二酮的菌株及其应用
摘要：
本发明涉及一株能将19‑去甲‑4‑雄烯二酮有效转化为16β‑羟基‑19‑去甲‑4‑雄烯二酮的黑曲霉(Aspergillus niger)(保藏编号：CGMCC No.15662)及其在转化甾体药物中的应用，属于微生物技术领域。本发明所述的菌株具有生长迅速，易于培养的特点，该菌株可高效的将19‑去甲‑4‑雄烯二酮有效转化为16β‑羟基‑19‑去甲‑4‑雄烯二酮，并且产物易于萃取分离，终产物纯度高。经检测，19‑去甲‑4‑雄烯二酮的生物转化率为80～90％，产物提取得率75～80％，16β‑羟基‑19‑去甲‑4‑雄烯二酮产品纯度大于99.5％。
摘要（英）：

The invention relates to a strain which is aspergillus niger capable of efficiently converting 19-normethyl-4-androstenedione to 16Beta-hydroxy-19-normethyl-4-androstenedione (preservation number: CGMCC No. 15662) and application of the strain to the conversion of steroidal drugs, and belong to the field of microbial technology. The strain provided by the invention has the characteristics of rapidgrowth and easiness in cultivation, and the strain can efficiently convert 19-normethyl-4-androstenedione into 16 beta-hydroxy-19-normethyl-4-androstenedione. The prepared product is easily extractedand separated, and has high purity. After testing, the biotransformation rate of 19-normethyl-4-androstenedione is 80-90%, the extraction yield of product is 75-80%, and the purity of 16beta-hydroxy-19-normethyl-4-androstenedione product is more than 99. 5%.

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