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发明公开
CN109081839A 小檗碱-邻苯二甲酸药物盐单晶体及其制备方法 失效 - 权利终止

小檗碱-邻苯二甲酸药物盐单晶体及其制备方法
摘要：
小檗碱-邻苯二甲酸药物盐单晶体及其制备方法，本发明提供了一种小檗碱药物盐单晶体的制备方法，本发明制备得到小檗碱-邻苯二甲酸药物盐单晶体，其化学式为C20H18NO4·C8H5O4，晶体结构属于三斜晶系，空间群为P，a=7.3443(6)Å，b=11.1081(9)Å，c=14.3643(11)Å，α=90°，β=99°，γ=97°，V=1144.18(16)Å3，Z=2。本发明制备得到的小檗碱-邻苯二甲酸药物盐单晶体，能够在保证小檗碱原有药物活性不变的前提下，有效地改善小檗碱的吸湿稳定性及其对大肠杆菌和金黄色葡萄球菌的抑菌活性，这对于改善小檗碱的理化性质及生物活性具有重要的学术探究意义及临床应用价值。
摘要（英）：

The invention relates to a berberine-phthalic acid medicine salt single crystal and a preparation method thereof. The chemical formula of the prepared berberine-phthalic acid medicine salt single crystal is C20H18NO4 C8H5O4, the crystal structure of the crystal belongs to a triclinic system, the space group of the crystal is P1, a=7.3443(6)angstrom, b=11.1081(9)angstrom, c=14.3643(11)angstrom, alpha=90 degrees, beta=99 degrees, gamma=97 degrees, V=1144.18(16)angstrom<3>, and Z=2. The prepared berberine-phthalic acid medicine salt single crystal has the advantages that the moisture absorption stability and antibacterial activity, to Escherichia coli and staphylococcus aureus, of berberine can be improved effectively under the premise that the activity of original medicine is kept unchanged,and the berberine-phthalic acid medicine salt single crystal has important academic research significance and clinical application value to the improvement of the physiochemical properties and biological activity of berberine.

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