The invention discloses a synthetic process of 3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidine-4-amine and belongs to the technical field of chemical synthesis of medicine. The synthetic process is characterized by including the steps of adding iodine, hydrogen peroxide, 4-aminopyrazolo[3,4-d]pyrimidine and a solid superacid gradually into acetic anhydride solution, and allowing reacting to obtain 3-iodo-4-aminopyrazolo[3,4-d]pyrimidine; dissolving the 3-iodo-4-aminopyrazolo[3,4-d]pyrimidine, 4-phenoxyphenylboronic acid and potassium phosphate in a mixed liquid of 1,4-dioxane and water, adding tetrakis(triphenylphosphine)palladium under argon protection, and allowing reacting to obtain 3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidine-4-amine. The synthetic process has the advantages of mild reaction conditions, good operational convenience, controllable cost and high yield.