The invention relates to the field of natural medicine and medicinal chemistry, in particular to enmein-type diterpene 14-OH spliced hydrogen sulfide donor derivatives, as well as their preparation method and application in the preparation of antitumor drugs. The enmein-type diterpene 14-OH spliced hydrogen sulfide donor derivatives and their pharmaceutically acceptable salts have a structure of formula I or II (shown in the description), wherein n is an integer of 0-12.