The invention relates to a paricalciferol soft capsule and a preparation method thereof, belonging to the field of pharmaceutical preparations. A soft capsule of paricalciferol comprises an active ingredient comprising paricalciferol and disodium monofluorophosphate, an antioxidant and a solvent, wherein the active ingredient comprises paricalciferol and disodium monofluorophosphate. The inventionoptimizes and screens the formula of paricalciferol soft capsule, Using propylene glycol and water as solvent, oil-soluble antioxidant and water-soluble antioxidant can effectively improve the stability of paricalciferol soft capsules, and paricalciferol and disodium monofluorophosphate combined treatment of osteoporosis, achieved unexpected synergistic effect.