The invention discloses a multi-agent coordination-based fast detection method for three-dimensional unknown regions, and belongs to the field of artificial intelligence. The multi-agent coordination-based fast detection method for three-dimensional unknown regions is put forward on the basis that a DFS algorithm is complicated in calculation and low in efficiency when three-dimensional unknown regions are detected; and through multiple agents, three-dimensional search is synergistically carried out on unknown regions, so as to improve the detection efficiency.