The invention relates to a method for synthesizing a thiophenes inhibitor TPCA-1, and belongs to the field of organic chemical drug synthesis. The method comprises the following steps: taking thioureaand 2-(4-fluorophenyl) cyclopropane-1,1-dimethyl isophthalate as starting raw materials, and the TPCA-1 is obtained through a multi-step reaction including a ring enlargement reaction, an oxidation reaction, an addition reaction and an amidation reaction in sequence. In the used route of the method, the reaction raw materials are easily obtained, the yield is high, and the TPCA-1 can be obtainedsuccessfully.