The invention discloses a high-speed train pneumatic noise reduction system and method. The system comprises a signal collector, a controller and two air gun generation devices, wherein the signal collector is connected with the controller; the controller is further connected with the two air gun generation devices; each air gun generation device comprises an air flow transmitter, a general air flow conduit, first supercharging equipment and second supercharging equipment; each supercharging equipment is connected with the general air flow conduit and the air inlet of the air flow transmitter;and the first supercharging equipment and the second supercharging equipment are connected with the controller. According to the system, the interference capacity of air jet on a boundary layer is combined with the pneumatic characteristic in a high-speed train moving process, on the premise of not changing the appearance and material of a train, the pneumatic characteristics, comfortable degreeand safety energy-saving performance of a train can be improved through a positive noise reduction system.