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发明公开
CN109535259A 用作诱发抗原特异性T细胞反应的免疫原性增强剂的融合蛋白 无效 - 撤回

用作诱发抗原特异性T细胞反应的免疫原性增强剂的融合蛋白
摘要：
本申请公开一种用作增强抗原特异性T细胞反应的免疫原增强剂的融合蛋白。所述融合蛋白包含：(a)抗原呈递细胞(APC)结合域或CD91受体结合域；(b)蛋白转导域；及(c)病原体的抗原，其中，所述APC结合域或CD91受体结合域位于所述融合蛋白的N端，且所述病原体的抗原位于所述蛋白转导域的C端。所述蛋白转导域选自：(i)融合多肽，其包含T细胞致敏信号转导肽、连接子及转位肽；(it)T细胞致敏信号转导肽；及(iii)长度为34-112个氨基酸残基的转位肽。
摘要（英）：

A fusion protein for use as immunogenic enhancers for inducing antigen-specific T cell responses is disclosed. The fusion protein comprises: (a) an antigen-presenting cell (APC)-binding domain or a CD91 receptor-binding domain; (b) a protein transduction domain; and (c) an antigen of a pathogen, wherein the antigen-presenting cell (APC)-binding domain or a CD91 receptor-binding domain is located at the N-terminus of the fusion protein, and the antigen of the pathogen is located at the C-terminus of the protein transduction domain. The protein transduction domain is selected from the group consisting of: (i) a fusion polypeptide comprising a T cell sensitizing signal transduction peptide, a linker and a transposable peptide; (it) a T cell sensitizing signal transduction peptide; and (iii) atranslocation peptide with a length of 34-112 amino acid residues.

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