The invention provides a method for designing an osculating axisymmetric Von Karman wave-rider fused with a low speed airfoil. The method for designing the osculating axisymmetric Von Karman wave-rider fused with the low speed airfoil comprises the steps of modifying a Von Karman curve revolving body bus into a pointed-end Von Karman curve revolving body bus; designing the pointed-end Von Karman curve revolving body bus; calculating a supersonic axisymmetric reference flow field around a zero-attack-angle pointed-end Von Karman curve revolving body; using the supersonic axisymmetric referenceflow field as an original reference flow field; and by using an osculating axisymmetric theory, generating a wave-rider three-dimensional reference flow field. The lower surface of the wave-rider is designed by using the method for designing the osculating axisymmetric Von Karman wave-rider to obtain an osculating axisymmetric Von Karman wave-rider surface; and the upper surface of the wave-rideris designed by using a low speed airfoil upper molded line in an osculating plane to obtain the upper surface fused with the low speed airfoil. According to the method for designing the osculating axisymmetric Von Karman wave-rider fused with the low speed airfoil, a problem that the bottom molded line of the shock wave of the wave-rider in an original Von Karman wave-rider designing method can only be the limitation of a circular arc is solved; and meanwhile, the low speed lift-drag ratio performance of the Von Karman wave-rider is improved; and the method for designing the osculating axisymmetric Von Karman wave-rider fused with the low speed airfoil is more beneficial for the wave-rider to be applied to wide speed range aircraft design.