The invention discloses an industrial production method of acotiamide hydrochloride. The industrial production method comprises the following steps that firstly, 2,4,5-trimethoxy benzoic acid serves as an initial raw material, acylating chlorination is carried out to prepare 2,4,5-trimethoxy benzoyl chloride, and then 2,4,5-trimethoxy benzoyl chloride and 2-aminothiazole-4-ethyl formate are subjected to amidation to prepare an intermediate II; secondly, the intermediate II is subjected to selective demethylation and re-crystallized with acetic acid to obtain an intermediate III; thirdly, the intermediate III and N,N-diisopropylamino are subjected to an ammonolysis reaction to prepare acotiamide; fourthly, acotiamide is subjected to salification and refining to prepare acotiamide hydrochloride. The intermediate in each step of the method is high in purity and high in yield, a final product is high in purity and environmentally friendly, the production is low, and the industrial production can be carried out.