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发明公开
CN109824489A 一种从甘草中提取的具有抗炎活性的化合物及其应用 无效 - 驳回

一种从甘草中提取的具有抗炎活性的化合物及其应用
摘要：
本发明公开一种从甘草中提取的具有抗炎活性的化合物及其应用。本发明所述化合物为新化合物，所述新化合物包括二氢茋类化合物和呋喃黄酮类化合物；所述二氢茋类化合物包括具有如式1和式2所示结构的组分：其中式1的R1＝OH，R2＝OCH3，R3＝OH，R4＝OH；其中式2的R1＝OH，R2＝OCH3，R3＝OH；所述呋喃黄酮类化合物包括具有如式3和式4所示结构的组分：其中式3的R1＝H，R2＝OH，R3＝OH，R4＝OH，R5＝OH，R6＝OH； 其中式4的R1＝OCH3，R2＝OH，R3＝H，R4＝OH，R5＝OH，R6＝OH；以及如式1-4其药学上可接受的盐。本发明得到的新化合物对炎症因子一氧化氮具有较高的抑制率，在研发新型抗炎药和合理利用甘草资源方面前景良好。
摘要（英）：

The invention discloses a compound with anti-inflammatory activity extracted from liquorice and an application thereof.The compound disclosed is a novel compound, and the novel compound comprises dihydrogenstilbene compounds and furan flavonoid compounds; the dihydrogenstilbene compounds comprise a component with a structure shown in the description such as a formula 1 and a formula 2, wherein R1of the formula 1 is equal to OH, R2 is equal to OCH3, R3 is equal to OH, and R4 is equal to OH; R1 of the formula 2 is equal to OH, R2 is equal to OCH3, R3 is equal to OH; the furan flavonoid compounds comprise a component with a structure shown in the description such as a formula 3 and a formula 4, wherein R1 of the formula 3 is equal toH, R2 isequal to OH, R3 is equal toOH, R4 is equal toOH, R5is equal toOH, and R6 is equal toOH;R1 of the formula 4 isequal to OCH3, R2 is equal to OH, R3 is equal to H, R4 is equal to OH, R5 is equal to OH, R6 is equal to OH; the compound also includes pharmaceutically acceptable salt asin formula 1-4.The obtainednovel compound has higher inhibition rate on inflammatory factor nitric oxide, and the prospect in aspects of researching and developing novelanti-inflammatory drugs and reasonably utilizing liquorice resources is good.

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