The invention discloses a thermal coupling air separation equipment energy consumption monitoring system based on hybrid modeling. The thermal coupling air separation equipment energy consumption monitoring system based on hybrid modeling is used for carrying out real-time monitoring and operation optimization on thermal coupling air separation equipment and comprises a mechanism statistics hybridmodeling module, an energy consumption calculation module and a product extraction rate calculation module. The product extraction rate and an equipment energy consumption value are transmitted to acontrol station and a storage system through a bus. The invention aims to overcome the defects of low on-line operation efficiency and poor model precision of an existing thermal coupling air separation model. By combining a mechanism model with high expansibility and high precision to a high-efficiency statistical model capable of utilizing a large number of production historical data, a hybrid energy consumption monitoring model with both accuracy and efficiency for the thermal coupling air separation equipment is established, and on this basis, the energy consumption monitoring system of the thermal coupling air separation equipment based on hybrid modeling is realized. The advantages of high precision of the mechanism model and high efficiency of the statistical model can be well combined; and the accuracy is high, the operation speed is high, and therefore, an efficient and accurate energy consumption monitoring effect is achieved.