The invention discloses an acquisition, operation and maintenance closed-loop processing simulation system based on man-machine-object fusion, and belongs to the technical field of electric power. Anexisting simulation system is inconsistent with a collection, operation and maintenance process and does not conform to an abnormal actual generation rule, and the abnormal type capable of being simulated is single. The simulation scene of the existing system is greatly different from the actual scene on site, so that abnormal defect elimination is easy to fail. The acquisition, operation and maintenance closed-loop processing simulation system is provided with a simulation master station, a simulation cabinet and an acquisition, operation and maintenance handheld machine; a simulation masterstation (person), a simulation cabinet (machine) and an acquisition operation and maintenance handheld machine (object) can be combined, an existing acquisition operation and maintenance closed-loop process and a generation rule are fused, an on-site real scene is restored to the maximum extent, the service level of acquisition operation and maintenance personnel is improved, and finally the purpose of improving the acquisition abnormal operation and maintenance quality is achieved.