The invention provides a vehicle-mounted mobile measurement system calibration method based on a global positioning control point coordinate. The method comprises the following steps of unifying GNSSobservation data, a precision ephemeris and surrounding IGS station information into a WGS-84 coordinate system; carrying out a baseline solution on the GNSS observation data corresponding to each control point so as to obtain an integer solution of a baseline vector; using an IGS station coordinate to improve accuracy of a starting point and carrying out constraint adjustment with a GNSS network;and verifying a vehicle-mounted mobile measurement system based on a global coordinate value of the control point obtained in a step 8.3. The method has the following advantages that a static relative positioning technology and an IGS station are directly used to jointly measure so as to obtain high-precision control point information; the coordinate under an unified WGS-84 coordinate system is used for calibration so as to avoid an error caused by the inaccurate control point and improve control point accuracy; and simultaneously, the error caused by multiple coordinate transformation is avoided and calibration precision is increased.