The invention relates to the field of intelligent transportation, in particular to a route point positioning method based on BIM+GIS, which comprises the following steps of: step 1, extracting interval information of a route, the interval information comprising a starting point mileage stake number, an end point mileage pile number, a starting point coordinate and an end point coordinate; step 2,with the mileage stake number or the point coordinate as a query condition, constructing a query condition-interval information query database; step 3, receiving input mileage stake numbers or point coordinates, and inquiring conditions from the input mileage stake numbers or the point coordinates; inquiring target interval information in an interval information inquiry database; step 4, accordingto the mileage pile number and the target interval information, calculating coordinates corresponding to the mileage pile number by adopting a spatial geometric function; or, according to the point coordinates and the target interval information, calculating the mileage pile number corresponding to the point coordinates by adopting a spatial geometric function. The method is high in calculation efficiency and positioning precision. The invention also provides a device and a system adopting the positioning method.