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发明公开
CN110128305A 二甲双胍-甲苯磺丁脲新盐型、其制备方法及医药用途 无效 - 撤回

二甲双胍-甲苯磺丁脲新盐型、其制备方法及医药用途
摘要：
本发明公开了一种二甲双胍-甲苯磺丁脲新盐型、其制备方法及医药用途。其制备方法为：将二甲双胍与甲苯磺丁脲溶解于适当溶剂中，反应结晶，过滤干燥，操作简单，重现性好，易于控制。本发明提供的二甲双胍-甲苯磺丁脲盐型，相较于二甲双胍单品的吸湿性及稳定性有很大的提高，相较于甲苯磺丁脲单品的溶解性有很大的提高，同时其制备方法操作简单，结晶过程易于控制，且盐型的重现性好。
摘要（英）：

The invention discloses a metformin-tolbutamide new salt type and a preparation method and medical application thereof. The preparation method comprises the following steps: dissolving metformin and tolbutamide in an appropriate solvent, reacting, crystallizing, filtering and drying. The preparation method has simple operation, good reproducibility and easy control. The hygroscopicity and stability of the metformin-tolbutamide new salt type are greatly improved compared with that of a metformin single product, the solubility of the metformin-tolbutamide new salt type is greatly improved compared with that of a tolbutamide single product, the preparation method is simple, the crystallization process is easy to control, and the metformin-tolbutamide new salt type has good repeatability.

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