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发明公开
CN110218168A 一种N-(全反式-视黄酰基)-L-半胱磺酸甲酯的钠盐的制备方法 有权

一种N-(全反式-视黄酰基)-L-半胱磺酸甲酯的钠盐的制备方法
摘要：
本发明公开了一种如式I-Na所示的N-(全反式-视黄酰基)-L-半胱磺酸甲酯的钠盐的制备方法。本发明所述的制备方法包括下述步骤：步骤1、在偶极非质子性溶剂中，在有机碱存在的条件下，将如式III所示的全反式视黄酸丁酸酐与如式II所示的L-半胱磺酸甲酯进行酰化反应，得到如式I所示的N-(全反式-视黄酰基)-L-半胱磺酸甲酯；步骤2、将步骤1中得到的如式I所示的N-(全反式-视黄酰基)-L-半胱磺酸甲酯制备成如式I-Na所示的N-(全反式-视黄酰基)-L-半胱磺酸甲酯的钠盐，即可。本发明所述的制备方法反应条件温和，操作简单，收率高，所得产品纯度高；生产成本低，设备要求低，适合工业化生产。
摘要（英）：

The invention discloses a preparation method of sodium salt of N-(all trans-retinol)-L-cystathionine methyl ester shown as formula I-Na. The preparation method comprises the following steps: step 1, in a dipolar aprotic solvent, performing acylation reaction on all-trans retinoic acid butyric anhydride shown in formula III and L-cystathionine methyl ester shown in formula II in the presence of organic base to obtain N-(all-trans-retinol)-L-cystathionine methyl ester shown in formula I; and step 2, prepare the n-(all trans-retinol)-l-cystathionine methyl ester shown in formula I obtained in thestep 1 into the sodium salt of n-(all trans-retinol)-l-cystathionine methyl ester shown in the formula I-Na. The preparation method disclosed by the invention has mild reaction conditions, simple operation, high yield and high purity of the obtained product. The production cost is low, the equipment requirement is low, and the method is suitable for industrial production.

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