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发明公开
CN110393824A 酯化琼脂糖-细胞复合纤维支架及其制备方法 无效 - 驳回

酯化琼脂糖-细胞复合纤维支架及其制备方法
摘要：
本发明涉及一种用于骨损伤修复的酯化琼脂糖-细胞复合纤维支架，其特征在于：包括酯化琼脂糖生物支架以及分布于所述酯化琼脂糖生物支架中的种子细胞，所述酯化琼脂糖生物支架为酯化琼脂糖、I型胶原和锰磷酸三钙的三元复合纳米纤维支架，复合纳米纤维的直径为500-600nm，所述锰磷酸三钙中锰元素的浓度为2.5-10mol％。该复合纤维支架具有生物安全性高、良好的生物相容性、取向性及多孔物理结构，加入生物活性的无机非金属，既优化了力学性能，又具有骨诱导活性，能够促进软骨细胞或骨髓间充质干细胞的粘附、增值、成软骨分化基因表达及骨细胞外基质的生成，加快骨愈合。
摘要（英）：

The invention relates to an esterified agarose-cell composite fiber scaffold for bone injury repair. The scaffold is characterized by comprising an esterified agarose biological scaffold and seed cells distributed in the esterified agarose biological scaffold, wherein the esterified agarose biological scaffold is a ternary composite nanofiber scaffold of esterified agarose, I-type collagen and manganese tricalcium phosphate, the diameter of the composite nanofiber is 500-600nm, and the concentration of manganese element in the manganese tricalcium phosphate is 2.5-10mol%. The composite fiber scaffold has high biological safety, and good biocompatibility, orientation and porous physical structure, and is added with bioactive inorganic nonmetal, so that the composite fiber scaffold not onlyoptimizes mechanical property, but also has bone induction activity, and can promote adhesion and proliferation of chondrocytes or bone marrow mesenchymal stem cells, chondrogenic differentiation geneexpression and bone extracellular matrix generation, and accelerate bone healing.

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