The invention relates to a power distribution network two-stage optimal regulation and control method and device based on a photovoltaic cluster. The method comprises the steps as follows: determininga first regulation and control scheme of a power distribution network according to the probability of occurrence of each operation scene of the power distribution network; performing global optimal regulation and control on the power distribution network according to the first regulation and control scheme; and when the node voltage in the photovoltaic cluster of the power distribution network exceeds the limit, determining a second regulation and control scheme based on the power regulation capability of the distributed photovoltaic and energy storage in the cluster, and regulating and controlling the distributed photovoltaic and energy storage in the photovoltaic cluster of the power distribution network by using the second regulation and control scheme. According to the technical scheme provided by the invention, multi-dimensional collaborative optimal regulation and control of various regulatable resources in the power distribution network in time scale and space scale are realized by utilizing two-stage regulation and control of the overall situation of the power distribution network and the photovoltaic cluster of the power distribution network, the rapidity and effectiveness of regulation and control are improved, the absorption capacity of the power grid for distributed photovoltaic is improved, and safe and stable operation of the power distribution network is ensured.