The invention relates to a rheumatoid arthritis scoring system based on multi-mode photoacoustic/ultrasonic imaging and an application of the rheumatoid arthritis scoring system. The application of multi-mode photoacoustic/ultrasonic imaging in the rheumatoid arthritis scoring system is characterized by comprising the following steps: (1) carrying out image information acquisition on joints through photoacoustic/ultrasonic bimodal imaging in an in-vitro mode; (2) analyzing the acquired image information and clinical data to carry out multi-mode photoacoustic/ultrasonic scoring; and (3) judgingdisease activity of rheumatoid arthritis patients according to the multi-mode photoacoustic/ultrasonic scoring combined with local blood oxygen information. The multi-mode photoacoustic/ultrasonic imaging system disclosed by the invention is used for evaluating rheumatoid arthritis for the first time, and has the advantages that a handheld photoacoustic/ultrasonic probe is adopted in the multi-mode photoacoustic/ultrasonic imaging system, the use of the handheld photoacoustic/ultrasonic probe accords with use habits of clinicians, the joint selection mode and is consistent with the joint selection mode of an international latest traditional ultrasonic evaluation, the implementation process and calculation process are simple and feasible, and clinical implementation and implementation arefacilitated.