The invention relates to an isolated DC micro-grid coordination method considering mismatched line resistance and local load. The method is characterized in that a virtual voltage is constructed through a dynamic consistency algorithm to replace an actual output voltage in traditional voltage-power droop control, the same actual output voltage reference is provided for droop control of a distributed power supply, and meanwhile, secondary voltage compensation is performed on a DC bus by using a PI controller to realize stable control on the voltage of the DC bus. Compared with the prior art, the method has the advantages that the output power distribution is more accurate, the voltage stability of the DC bus is improved, the method adapts to frequent changes of a DC micro-grid, and the dependence on a communication bus is reduced.