The invention discloses lycium barbarum polysaccharide yoghourt capable of protecting liver and dispelling effects of alcohol and a preparation method of the lycium barbarum polysaccharide yoghourt. The preparation method comprises the following steps: step 1, fermenting lycium barbarum polysaccharide by adopting a novel probiotic Ackerman mucophilic bacterium; step 2, mixing the lycium barbarum polysaccharide fermentation liquor with milk according to a certain proportion, step 3, uniformly stirring the materials and quickly cooling to 40-45 DEG C to obtain a mixture; step 4, inoculating probiotics into the mixture obtained in the step 3 for fermentation; and 5, performing standing for 8-12 hours at the temperature of 1-5 DEG C for after-ripening. The yoghourt provided by the invention isfine and smooth in tissue and free of whey precipitation, and has the effects of protecting the liver, dispelling the effects of alcohol and the like.