The invention relates to 2-amino pyrimidine derivative, a preparation method thereof and an application thereof in medicine. In particular, the present invention relates to a 2-amino pyrimidine derivative shown in the general formula (I), a preparation method thereof, a pharmaceutical composition containing that derivative and use thereof as therapeutic agent, in particular as an A2a receptor and/or A2b receptor antagonist and in the preparation of a drug for the treatment of a condition or disorder improved by inhibition of the A2a receptor and/or A2b receptor, wherein the substituents of thegeneral formula (I) are the same as defined in the specification.