The invention discloses a type of novel 3-amino alkyl phthalein compound (I) as well as a pharmaceutical acceptable salt, a preparation method, a medicine composition and application thereof in preparing medicines for treating and/or preventing diseases associated with nervous systems, and the diseases comprise but not limited to, vascular dementia, Alzheimer's disease, Parkinson's disease, Huntington's disease, HIV (human immunodeficiency virus) related dementia, multiple sclerosis, muscular atrophy amyotrophic lateral sclerosis, neuropathic pain, glaucoma, ischemic stroke, hemorrhagic stroke, nerve damage caused by brain injury, and the like.