The invention discloses a non-uniform cooling slab crystallizer. The non-uniform cooling slab crystallizer comprises a copper plate, wherein the copper plate comprises a first region, a second regionand a third region, bolt holes are uniformly formed in the front surface of the copper plate, and the spacing distance between the two adjacent bolt holes 5 is 80-250 mm, the number of vertical alignment of the bolt holes is 6-12, the front surface of the copper plate is uniformly provided with thermocouple holes, the thermocouple holes and the bolt holes are in the same vertical horizontal line,the front surface of the copper plate is uniformly provided with cooling water tanks, and 3-8 cooling water tanks are distributed between the two adjacent bolt holes, the depth, close to one sides ofthe bolt holes, of the cooling water tanks is 12-18 mm, the depth of the other cooling water tanks is 8-14 mm, and the width of the cooling water tanks is 5-12 mm. The water amount of the crystallizerin different regions is dynamically and flexibly adjusted according to the solidification characteristics of different steel types in the crystallizer, the safety thickness of a casting blank shell is not only guaranteed, but also slab cracks is reduced and even the occurrence of leakage steel accidents is reduced.