The invention belongs to the technical field of engines, and particularly relates to a cylinder sleeve, an engine with the same and a design method of the cylinder sleeve. The cylinder sleeve comprises a cylinder sleeve body, a first lubricating area and a second lubricating area located below the first lubricating area are arranged on the inner wall of the cylinder sleeve body, a plurality of first concave pits are formed in the first lubricating area, a plurality of second concave pits are formed in the second lubricating area, and the diameter-to-depth ratio of the first concave pits is smaller than that of the second concave pits. According to the cylinder sleeve, the small and deep first concave pits are formed in the first lubricating area, the oil film of the first lubricating areais increased, thus friction force of the first lubricating area is lowered, and the situation that a piston or the cylinder sleeve is abraded too early is avoided; the large and shallow second concavepits are formed in the second lubricating area, and one part of lubricating oil enters the large and shallow concave pits. On the condition that the oil scraping capability of a piston ring is certain, the thickness of oil film distributed in the second lubricating area is reduced, and thus resistance to motion of the piston is reduced.