The invention discloses an anti-fatigue hunger-resistant food additive as well as a preparation method and application thereof. The food additive comprises the following components: taurine, inositol,lysine, vitamin B1, vitamin B6, vitamin B12, vitamin E, astragalus polysaccharide and konjac polysaccharide. The preparation method comprises the step of mixing the components. According to the application, the anti-fatigue hunger-resistant food additive is added according to the proportion of 2-8% of the mass of staple food or non-staple food raw materials. The anti-fatigue hunger-resistant foodadditive is high in anti-fatigue and hunger-resistant effect, has the effects of relieving exercise-induced fatigue and chronic anti-fatigue, and is low in cost and safe and reliable in formula. Themethod is simple in process, low in cost and suitable for industrial production. The anti-fatigue hunger-resistant food additive can be widely applied to staple food or non-staple food raw materials.