The invention discloses a fully-automatic high-place expansion bolt screwing-in machine. The fully-automatic high-place expansion bolt screwing-in machine comprises a drive mechanism, a rotation mechanism and an ascending mechanism, wherein the drive mechanism drives the rotation mechanism and the ascending mechanism to simultaneously act to realize expansion bolt screwing-in; the drive mechanismcomprises a drive motor, a shaft coupler, drive gears, a drive shaft and a synchronous shaft; the transmission shaft of the drive motor is coaxially connected to the drive shaft through the shaft coupler; and the drive gear is rigidly connected to the drive gear. While the fully-automatic high-place expansion bolt screwing-in machine accomplishes work, an expansion bolt is automatically screwed infrom the machine, so that both hands of a worker are released, and therefore, working efficiency is improved; the position of the ascending mechanism and the rotation mechanism are uniformly distributed on a supporting plate, so that accuracy of an expansion bolt ascending direction is guaranteed, and manual screwing-in errors are greatly avoided.