The invention provides a tumor puncture real-time simulation device and method. The tumor puncture real-time simulation device comprises four metal points, a puncture needle, CT scanning equipment andRFID tag readers. The four metal points are arranged at optional positions of a patient's body; RFID radio-frequency tags are arranged at the tail end of the puncture needle and at a position, away from the tail end by a preset distance, of the puncture needle respectively; the CT scanning equipment is used for CT scanning of the patient to determine tumor positions of the patient, generating space coordinates of the patient according to position information of the four metal points in a CT scanning image, determining a puncture route according to the CT image and sending a CT image of a plane of the puncture route to display equipment to realize displaying; the RFID tag readers are used for reading real-time positions of the two RFID radio-frequency tags on the puncture needle and displaying the same in the CT image of the plane of the puncture route.