The invention discloses a Q345C steel plate for a railway bogie and a manufacturing method of the Q345C steel plate. Through low-C, microalloy and low-impurity content component design concept, it iseffectively guaranteed that the steel plate delivery state strength and simulated postwelding strength meet the technical requirements, and the situation that the delivery state strength meets the requirement, the simulated postwelding strength is reduced, and consequently the simulated postwelding strength is disqualified is avoided. The clean steel smelting technology is adopted in the manufacturing method of the Q345C steel plate, the content of gas and nonmetal inclusions is reduced, oxidization is avoided in the whole process of the continuous casting procedure, in combination with the solidification tail end soft pressing and electromagnetic stirring technology, a high-purity and high-cleanliness continuous casting blank is obtained, and it is ensured that the casting blank is flat and inner metal is dense. Through the two-stage rolling technology, the grain size of austenite and ferrite is refined, and an inner structure with fine ferrite as a base body and with evenly-distributed pearlite is obtained. The obtained steel plate has excellent low-temperature impact toughness, good welding performance and a high structure purity degree, and the current railway bogie technical requirements can be met.