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CN1305847A 以环糊精为偶联剂的单抗药物偶联物 无效 - 撤回

以环糊精为偶联剂的单抗药物偶联物
摘要：
以环糊精分子为偶联剂,以适当方法获得抗Ⅳ型胶原酶单抗3D6 Fab’片段,将Fab’片段与平阳霉素偶联,获得偶联物Fab’－平阳霉素,分光光度法测定结果表明偶联物分子量为68kDa,偶联物对人口腔鳞癌KB细胞、小鼠肝癌22细胞等呈阳性免疫反应,以克隆形成法检测偶联物对体外培养的KB细胞的杀伤作用,结果表明偶联物对靶细胞KB的作用强于平阳霉素,体内实验用肝癌22模型,Fab’－平阳霉素偶联物抑制肝癌生长作用明显强于等剂量平阳霉素,确定以环糊精作为偶联剂可制备新型、有效的抗肿瘤单抗导向药物并用于肿瘤治疗。
摘要（英）：

A conjugate of monoclonal antibody medicine using cyclodextrin as coupling agent is disclosed, which can be used to prepare new antineoplastic medicines. The anti-IV type collegenase monoclonal antibody 3D6Fab' fragment is obtained by proper method. said Fab' fragment is coupled with Pingyangmycin to obtain the conjugate "Feb'-Pingyangmycin". Said conjugate has 68KDa of molecular weight and stronger suppression action to liver cancer. It shows positive immune reaction to human oral squamous cancer KB cell and mouse's liver cancer cell "22".

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