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发明公开
CN1850790A 5,5,5,三氟甲基－4－(2－苯腙)戊酸甲酯及其合成方法 失效 - 权利终止 转让

5,5,5,三氟甲基－4－(2－苯腙)戊酸甲酯及其合成方法
摘要：
本发明涉及一种新的化合物2－苯基－6－三氟甲基－4，5－二氢哒嗪－3(H)－酮的合成，其特征在于，该化合物具有如下结构：该化合物的合成方法为：氮气保护下，在反应容器中加入5，5，5－三氟甲基－4－羰基－戊酸甲、苯肼、乙酸和乙酸钠缓冲溶液。加热回流，反应36～64小时后，最后用柱层析的分离，得到此新化合物2－苯基－6－三氟甲基－4，5－二氢哒嗪－3(H)－酮。本发明具有原料易得，操作非常简单，产率高，分离简便等优点，适合于工业生产。此发明不仅在化合物中引进了具有生理活性含氟基团，而且也在化合物中形成了药物中间体－哒嗪酮。
摘要（英）：

This invention relates to synthesis of new compound 2-benzene group-6- trifluoromethyl-4, 5- dihydro pyridazine-3(H)-ketone. Its structure formula is shown as follow. 5, 5, 5-trifluoromethyl-4-carbonyl-valeric acid, phenyl hydrazine, acetic acid and sodium acetate buffer solution are added into the reactor. Then they are heated and back flown, after the reaction kept 36-64 hours, column chromatography separation is used to get the new compound. The material in this invention is easy to get, operation is simple, yield is high and its separation is convenient, it is propitious to industrial manufacture. Biological active fluorine basal group is brought in the compound, and medicine pyridezinone intermediate is also formed in the compound.

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