The utility model discloses a live working manipulator for replacing an insulator string, and belongs to the technical field of power transmission and distribution projects. The manipulator comprises four parts, namely a locating mechanism, a pin clamping mechanism, a driving mechanism and a working condition display lamp. The manipulator is born in a horizontal plane by an insulating rod to work and is hung in a vertical plane by an insulation rope to work. The locating mechanism can precisely hold a socket and the display is in place by a horizontal lamp and a vertical lamp. The pin clamping mechanism can hold a W pin for dismounting and mounting. The driving mechanism can drive the pin clamping mechanism to realize clamping, releasing, driving and retreating of a clamp. When the clamp is in place, clamping is displayed by a clamp lamp and a limit lamp. The insulator string can be replaced continuously. The manipulator is simple in structure, reliable in working, high in precision, time-saving and labor-saving, and is used for maintenance of high-voltage lines.