The utility model relates to a multi -functional automatic positioning mechanism of large -scale civil airplane cargo door, including the guide way structure, install on fuselage mouth frame, set up the dog on the guide way top, correspond the guide way side on the dog and set up and close the spigot surface and constitute, bearing installation is on hatch door mouth frame, and support one side is connected with the promotion leading wheel, and the leading wheel is closed with promoting to install to the support between the leading wheel, the axis of closing the leading wheel and promoting the leading wheel is mutually perpendicular, hatch door hoist mechanism is connected to the support opposite side, in the guide way was arranged in to the promotion leading wheel, along the guide way motion, when the hatch door lifter motion, the guide way motion was followed to the promotion leading wheel on the support, closes the leading wheel and closes the spigot surface contact, moves along closing the spigot surface, realizes guiding orientation. The utility model discloses make the hatch door can rely on the automatic accurate positioning of self gravity realization hatch door in the process of closing, attach the indispensable multiple functions of civil airplane hatch door simultaneously.