The utility model discloses a thermos bottle inner container protection frame device with a compression spring. The thermos bottle inner container protection frame device comprises a protection framebody, a plug, the compression spring and a thermos bottle body. The protective frame body comprises an outer ring, an inner ring and an annular groove, and the thermos bottle body comprises an inner container and a shell. The outer ring is designed to be a boss, the inner ring is designed to be a circular ring, and the annular groove is designed to be a groove. The protection frame body is clampedbetween the inner container and the outer shell in an interference mode through the outer ring and the inner ring. The compression spring is mounted at the bottom of the outer ring pit and is alwaysin a compressed state; the plug is arranged at the opening part of the pit and is in interference fit; the protection frame body is provided with a double anti-skid structure, and the first anti-skidstructure is designed to always provide compression elastic force through a compression spring, so that the protection frame body is always tightly attached to the inner container and the shell. And the second anti-skid structure is designed into a structure similar to a sucker among the annular groove, the inner ring and the inner container by utilizing the groove of the annular groove under theaction of compression elastic force. The structure is simple, installation is convenient and reliable, and the service life of the thermos bottle is prolonged.