发明公开
EP0002066A1 2-Adamantyl hydrazines and pharmaceutical compositions containing them
失效
2- Adamantylhydrazine和含有它们的药物组合物。
- 专利标题: 2-Adamantyl hydrazines and pharmaceutical compositions containing them
- 专利标题(中): 2- Adamantylhydrazine和含有它们的药物组合物。
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申请号: EP78101412.1申请日: 1978-11-20
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公开(公告)号: EP0002066A1公开(公告)日: 1979-05-30
- 发明人: Weiner, Ben Zion , Suchi, Raul , Sterling, Jeffrey , Yellin, Haim
- 申请人: Teva Pharmaceutical Industries Limited
- 申请人地址: Har Hotzvim behind Sanhedria Ha'Murhevet Jerusalem IL
- 专利权人: Teva Pharmaceutical Industries Limited
- 当前专利权人: Teva Pharmaceutical Industries Limited
- 当前专利权人地址: Har Hotzvim behind Sanhedria Ha'Murhevet Jerusalem IL
- 代理机构: Brown, John David
- 优先权: IL53440 19771122
- 主分类号: A61K31/15
- IPC分类号: A61K31/15 ; C07C109/00 ; C07C109/04 ; C07D295/22 ; C07D213/77 ; C07D215/42 ; C07D233/80
摘要:
The invention provides novel 2-adamantyl hydrazine derivatives of the general formula A
In this formula R, is hydrogen or a lower alkyl group of 1-4 carbon atoms; R 2 and R 3 are the same or different and are each hydrogen, an unsubstituted or substituted radical being a lower alkyl of 1-4 carbon atoms, a lower alkanoic acid radical of 2-4 carbon atoms or a lower alkyl ester thereof, adamantyl, aryl, aralkyl, in which the alkyl moiety has from 1-4 carbon atoms or an unsubstituted or substituted heterocyclic radical of aromatic character; or R 2 and R 3 together with the nitrogen atom to which they are attached form an unsubstituted or substituted non-aromatic cyclic radical.
The invention further provides pharmaceutically acceptable acid addition salts of the above compounds.
Several methods of preparation of the new compounds are described.
The novel compounds according to the invention possess valuable antifungal (human and plant), antiviral, antiprotozoal and antimicrobial properties.
In this formula R, is hydrogen or a lower alkyl group of 1-4 carbon atoms; R 2 and R 3 are the same or different and are each hydrogen, an unsubstituted or substituted radical being a lower alkyl of 1-4 carbon atoms, a lower alkanoic acid radical of 2-4 carbon atoms or a lower alkyl ester thereof, adamantyl, aryl, aralkyl, in which the alkyl moiety has from 1-4 carbon atoms or an unsubstituted or substituted heterocyclic radical of aromatic character; or R 2 and R 3 together with the nitrogen atom to which they are attached form an unsubstituted or substituted non-aromatic cyclic radical.
The invention further provides pharmaceutically acceptable acid addition salts of the above compounds.
Several methods of preparation of the new compounds are described.
The novel compounds according to the invention possess valuable antifungal (human and plant), antiviral, antiprotozoal and antimicrobial properties.
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