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114 条记录 (耗时 0.013 秒)

    DÉRIVÉS DE 2-PYRIDIN-2-YL-PYRAZOL-3(2H)-ONE, LEUR PRÉPARATION ET LEUR APPLICATION EN THÉRAPEUTIQUE
    3.
    发明公开
    DÉRIVÉS DE 2-PYRIDIN-2-YL-PYRAZOL-3(2H)-ONE, LEUR PRÉPARATION ET LEUR APPLICATION EN THÉRAPEUTIQUE 有权
    的2-吡啶-2-基吡唑-3-（2H） - 酮衍生物，其制备及其治疗用途

    公开(公告)号：EP2382215A1

    公开(公告)日：2011-11-02

    申请号：EP09805790.4

    申请日：2009-12-24

    申请人： SANOFI

    发明人： ALTENBURGER, Jean-Michel ,  FOSSEY, Valérie ,  ILLIANO, Stéphane ,  MANETTE, Géraldine

    IPC分类号： C07D471/04 ,  C07D491/04 ,  C07D513/04 ,  A61K31/4162 ,  A61P27/06 ,  C07D213/72 ,  C07D213/77 ,  C07D401/12 ,  C07D405/12 ,  C07D409/12 ,  C07D403/04 ,  C07D495/04

    CPC分类号： C07D401/14 ,  C07D401/04 ,  C07D403/04 ,  C07D471/04 ,  C07D491/052 ,  C07D495/04

    摘要： The invention relates to compounds with the formula (I), in a basic state or as an acid addition salt: (I) where n is equal to 0, 1, 2, 3 or 4; m is equal to 0, 1 or 2; o is equal to 0 or 1; X is a -CH
    2, - CH(R')-, -NH(R')- group or a heteroatom selected from among O and S, where R' is a -(C1 -C5)alkyl, -(C1-C5)alcoxy, -CH
    2 -aryl, -C(O)R5 or -COOR5 group; R1 is an oxo, -COOR5, -W-OH or -W-NR5R6 group; R2 is an H atom or a group selected from among the following groups: (i) -(C1 -C5)alkyl, (ii) -(C1-C5)alcoxy, (iii) -COOR5, (iv) -NR5R6, (v) -C(O)-NR5R6, (vi) -SO
    2 -N R3R4, (vii) heteroaryl optionally substituted by a -(C1-C5)alkyl group, (viii) -W-aryl, (ix) -W-heteroaryl, (x) -O-W-aryl, (xi) -O-W-heteroaryl and (xii) -O-W-NR5R6; where R3 and R4, which may be identical or different, (i) independently from one another are an H atom, a -(C1-C5)alkyl, -(C3-C6)cycloalkyl, aryl, heteroaryl, -CH
    2 -heteroaryl, -(C1-C5)alkyl-NR5R6, -W-OH or -W-NR5R6 group; or (ii) together with the nitrogen atom that carries them, jointly form a heterocycloalkyl group, optionally substituted by one or more groups selected from among the -(C1-C5)alkyl and -CH
    2 -aryl groups; W is a -(C1-C5)alkylene group, optionally substituted by one or more hydroxy groups; R5 and R6, which may be identical or different, independently from one another are a hydrogen atom or a group selected among the -(C1-C5)alkyl groups and the -(C3-C6)cycloalkyl groups, as well as to the preparation method and to the therapeutic uses of said compounds.