公开(公告)号：EP0183532A3

公开(公告)日：1988-01-27

申请号：EP85308605

申请日：1985-11-27

申请人： Lilly Industries Limited

发明人： Finch, Mark Andrew William ,  Harris, John Richard

IPC分类号： C07C59/64 ,  C07C69/732 ,  C07D211/00 ,  C07C109/00 ,  C07C131/00 ,  C07C49/217 ,  C07C135/00 ,  A61K31/19

CPC分类号： C07D295/185 ,  C07C47/27 ,  C07C47/277 ,  C07C47/565 ,  C07C47/575 ,  C07C49/835 ,  C07C49/84 ,  C07C251/72 ,  C07D295/145 ,  C07D295/30 ,  Y02P20/55

摘要： Compounds are described of the following formula

in which R' and R 2 are each hydrogen, C, 12 alkyl or C 2-12 alkenyl, at least one of R' and R 2 being C 1 12 alkyl or C 2 12 alkenyl; X' and X 2 are each hydrogen or a protecting group; and Y is
(a) -(CH=CH) n Z in which n is 1, 2 or 3 and Z is -CHO, -CH 2 ,OH, -COR 3 , -(CH 2 ) m -COR 3 or -(CH 2 ) p CH=CH(CH 2 ) q -COR 3 in which m is an integer of 1 to 12, p is an integer of 1 to 4, q is an integer of 1 to 10 and R 3 is (i) -OH or (ii) -NR 4 R 5 where R 4 and R 5 are each hydrogen, C 1 4 alkyl or optionally substituted phenyl, or R 4 and R 5 together with the nitrogen atom to which they are attached form a morpholino, pyrrolidinyl or piperidino ring, (b) -CH=NR 6 in which R 6 is (i) -OH, (ii) C 1 12 alkyl optionally substituted by -OH, -COOH or -NR 7 R 8 where R 7 and R 8 are each hydrogen or C, 4 alkyl, (iii) optionally substituted phenyl or (iv) -NR 9 R 10 in which R 9 is hydrogen and R 10 is optionally substituted phenyl or C 1 4 alkylCO-, or in which R 9 and R 10 together with the nitrogen atom to which they are attached form a morpholino, pyrrolidinyl or piperidino ring, (c) -CH 2 NHR" in which R" is C 1 12 alkyl optionally substituted with hydroxy or carboxy or optionally substituted phenyl, or (d) -CHOHR 12 or
in which R 12 is hydrogen or C 1-12 alkyl; and lactones, salts and esters thereof; provided that when one of R' and R 2 is hydrogen and the other is C 1 12 alkyl, Y is -(CH=CH) n Z, n is 1 and Z is -COOH only salts are included. The compounds have pharmaceutical activity.

公开(公告)号：EP0001415A1

公开(公告)日：1979-04-18

申请号：EP78100932.9

申请日：1978-09-19

申请人： Agfa-Gevaert AG

发明人： Wernicke, Ubbo, Dr.

IPC分类号： G03C5/50 ,  C07C109/00 ,  C07C83/10

CPC分类号： G03C5/50

摘要： Die Beständigkeit bekannter photographischer Verschleierungsbäder ist unbefriedigend. Es wurden Verschleierungsmittel enthaltende photographische Bäder gefunden. insbesondere Zinn-II-lonen-haltige Verschleierungsbäder mit einem Zusatz einer Verbindung bzw. eines Tautomeren davon oder eines Salzes dieser Verbindung, welche folgender Formel entspricht, wobei die Substituenten die in der Beschreibung angegebene Bedeutung haben:

摘要翻译： 已知的照相起雾浴的电阻是不令人满意的。 有防雾剂发现的包含照相浴，特别是亚锡含离子隐蔽浴在加入的化合物或其互变异构体或该化合物的盐，其对应于下式其中取代基具有本说明书中给出的含义：< IMAGE>

公开(公告)号：EP0034945A3

公开(公告)日：1982-04-21

申请号：EP81300767

申请日：1981-02-24

申请人： MAY & BAKER LIMITED

发明人： Hatton, Leslie Roy ,  Parnell, Edgar William ,  Roberts, David Alan

IPC分类号： C07D231/38 ,  A01N43/56 ,  C07C109/00 ,  C07C87/52 ,  C07C87/60 ,  C07C121/78 ,  C07C79/12 ,  C07C121/52

CPC分类号： C07D231/38 ,  A01N43/56 ,  A01N47/02 ,  C07C243/00 ,  C07C255/00

摘要： N-Phenylpyrazole derivatives of the formula:-
(wherein each of R 5 and R 6 represents a C 1 -C 4 alkyl or alkoxy radical, a trifluoromethyl, trifluoromethoxy, nitro, cyano or primary amino radical, or a fluorine, chlorine or bromine atom, each of R', R' and R 9 represents a hydrogen atom, a C 1 -C 4 alkyl or alkoxy radical, a trifluoromethyl, trifluoromethoxy, nitro, cyano or primary amino radical or a fluorine, chlorine or bromine atom, or R 5 , R 7 , R' and R 9 each represents a hydrogen atom and R 6 represents a trifluoromethoxy or trifluoromethyl radical, and R 10 represents a cyano radical or substituted carbamoyl radical -CONHR", wherein R" represents a methyl or ethyl radical) have been found to possess useful herbicidal properties. All such N-phenylpyrazole derivatives with the exception of 5-amino-4-cyano-1-(2,4-dichlorophenyl)pyrazole and 5-amino-4-cyano-1- (4-chloro-2-methylphenyl)pyrazole are new compounds. Herbicidal compositions containing such N-phenylpyrazole derivatives are described and also processes for the prepararation of the new compounds.

公开(公告)号：EP0002065A1

公开(公告)日：1979-05-30

申请号：EP78101411.3

申请日：1978-11-20

申请人： Teva Pharmaceutical Industries Limited

发明人： Weiner, Ben-Zion ,  Suchi, Raul ,  Sterling, Jeffrey ,  Yellin, Haim

IPC分类号： A61K31/15 ,  C07C109/00 ,  C07C109/04 ,  C07D295/22 ,  C07D213/77 ,  C07D215/42 ,  C07D233/80

CPC分类号： C07D213/77 ,  C07C243/00 ,  C07D215/42 ,  C07D233/80 ,  C07D295/30

摘要： The invention provides novel 1- or 2-adamantylmethyl hydrazines of the general formulaA

In this formula Ad is 1- or 2-adamantyl, R 1 and R 2 are the same or different and are each hydrogen or a lower unsubstituted or substituted alkyl group of 1-4 carbon atoms; R, and R 4 are the same or different and are each hydrogen, an unsubstituted or substituted radical being a lower alkyl group of 1-4 carbon atoms, a lower alkanoic acid radical of 2-4 carbon atoms or a lower alkyl ester thereof, adamantyl, aryl, aralkyl in which the alkyl moiety has 1-4 carbon atoms or an unsubstituted or substituted heterocyclic radical of aromatic character; or R 3 and R 4 together with the nitrogen atom to which they are attached form a cyclic radical of non-aromatic character.
The invention further provides pharmaceutically acceptable acid addition salts of the above compounds.
Several methods of preparation of the new compounds are described.
The novel compounds according to the invention possess valuable antifungal (human and plant), antiviral, antiprotozoal and antimicrobial properties.

公开(公告)号：EP0183532A2

公开(公告)日：1986-06-04

申请号：EP85308605.6

申请日：1985-11-27

申请人： Lilly Industries Limited

发明人： Finch, Mark Andrew William ,  Harris, John Richard

IPC分类号： C07C59/64 ,  C07C69/732 ,  C07D211/00 ,  C07C109/00 ,  C07C131/00 ,  C07C49/217 ,  C07C135/00 ,  A61K31/19

CPC分类号： C07D295/185 ,  C07C47/27 ,  C07C47/277 ,  C07C47/565 ,  C07C47/575 ,  C07C49/835 ,  C07C49/84 ,  C07C251/72 ,  C07D295/145 ,  C07D295/30 ,  Y02P20/55

摘要： Compounds are described of the following formula

in which R' and R 2 are each hydrogen, C, 12 alkyl or C 2-12 alkenyl, at least one of R' and R 2 being C 1 12 alkyl or C 2 12 alkenyl; X' and X 2 are each hydrogen or a protecting group; and Y is

(a) -(CH=CH) n Z in which n is 1, 2 or 3 and Z is -CHO, -CH 2 ,OH, -COR 3 , -(CH 2 ) m -COR 3 or -(CH 2 ) p CH=CH(CH 2 ) q -COR 3 in which m is an integer of 1 to 12, p is an integer of 1 to 4, q is an integer of 1 to 10 and R 3 is (i) -OH or (ii) -NR 4 R 5 where R 4 and R 5 are each hydrogen, C 1 4 alkyl or optionally substituted phenyl, or R 4 and R 5 together with the nitrogen atom to which they are attached form a morpholino, pyrrolidinyl or piperidino ring,
(b) -CH=NR 6 in which R 6 is (i) -OH, (ii) C 1 12 alkyl optionally substituted by -OH, -COOH or -NR 7 R 8 where R 7 and R 8 are each hydrogen or C, 4 alkyl, (iii) optionally substituted phenyl or (iv) -NR 9 R 10 in which R 9 is hydrogen and R 10 is optionally substituted phenyl or C 1 4 alkylCO-, or in which R 9 and R 10 together with the nitrogen atom to which they are attached form a morpholino, pyrrolidinyl or piperidino ring,
(c) -CH 2 NHR" in which R" is C 1 12 alkyl optionally substituted with hydroxy or carboxy or optionally substituted phenyl, or
(d) -CHOHR 12 or
in which R 12 is hydrogen or C 1-12 alkyl; and lactones, salts and esters thereof; provided that when one of R' and R 2 is hydrogen and the other is C 1 12 alkyl, Y is -(CH=CH) n Z, n is 1 and Z is -COOH only salts are included.

The compounds have pharmaceutical activity.

公开(公告)号：EP0002066B1

公开(公告)日：1983-05-25

申请号：EP78101412.1

申请日：1978-11-20

申请人： Teva Pharmaceutical Industries Limited

发明人： Weiner, Ben Zion ,  Suchi, Raul ,  Sterling, Jeffrey ,  Yellin, Haim

IPC分类号： A61K31/15 ,  C07C109/00 ,  C07C109/04 ,  C07D295/22 ,  C07D213/77 ,  C07D215/42 ,  C07D233/80

CPC分类号： C07D213/77 ,  C07C243/00 ,  C07D215/42 ,  C07D233/80 ,  C07D295/30

公开(公告)号：EP0001415B1

公开(公告)日：1981-06-17

申请号：EP78100932.9

申请日：1978-09-19

申请人： Agfa-Gevaert AG

发明人： Wernicke, Ubbo, Dr.

IPC分类号： G03C5/50 ,  C07C109/00 ,  C07C83/10

CPC分类号： G03C5/50

公开(公告)号：EP0002066A1

公开(公告)日：1979-05-30

申请号：EP78101412.1

申请日：1978-11-20

申请人： Teva Pharmaceutical Industries Limited

发明人： Weiner, Ben Zion ,  Suchi, Raul ,  Sterling, Jeffrey ,  Yellin, Haim

IPC分类号： A61K31/15 ,  C07C109/00 ,  C07C109/04 ,  C07D295/22 ,  C07D213/77 ,  C07D215/42 ,  C07D233/80

CPC分类号： C07D213/77 ,  C07C243/00 ,  C07D215/42 ,  C07D233/80 ,  C07D295/30

摘要： The invention provides novel 2-adamantyl hydrazine derivatives of the general formula A

In this formula R, is hydrogen or a lower alkyl group of 1-4 carbon atoms; R 2 and R 3 are the same or different and are each hydrogen, an unsubstituted or substituted radical being a lower alkyl of 1-4 carbon atoms, a lower alkanoic acid radical of 2-4 carbon atoms or a lower alkyl ester thereof, adamantyl, aryl, aralkyl, in which the alkyl moiety has from 1-4 carbon atoms or an unsubstituted or substituted heterocyclic radical of aromatic character; or R 2 and R 3 together with the nitrogen atom to which they are attached form an unsubstituted or substituted non-aromatic cyclic radical.
The invention further provides pharmaceutically acceptable acid addition salts of the above compounds.
Several methods of preparation of the new compounds are described.
The novel compounds according to the invention possess valuable antifungal (human and plant), antiviral, antiprotozoal and antimicrobial properties.