发明公开
- 专利标题： New lactyl tetrapeptide, processes for preparation thereof and pharmaceutical compositions containing it
- 专利标题（中）： 乳酰四肽，其制备方法和含有药物组合物的过程。
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申请号： EP79104479.5申请日： 1979-11-14
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公开(公告)号： EP0011283A1公开(公告)日： 1980-05-28
- 发明人: Kitaura, Yoshihiko , Nakaguchi, Osamu , Hemmi, Keiji , Aratani, Matsuhiko , Takeno, Hidekazu , Okada, Satoshi , Tanaka, Hirokazu , Hashimoto, Masashi , Kuroda, Yoshio , Iguchi, Eiko , Kohsaka, Masanobu , Aoki, Hatsuo , Imanaka, Hiroshi
- 申请人： FUJISAWA PHARMACEUTICAL CO., LTD.
- 申请人地址： 3, Doshomachi 4-chome Higashi-ku Osaka-shi Osaka 541 JP
- 专利权人： FUJISAWA PHARMACEUTICAL CO., LTD.
- 当前专利权人： FUJISAWA PHARMACEUTICAL CO., LTD.
- 当前专利权人地址： 3, Doshomachi 4-chome Higashi-ku Osaka-shi Osaka 541 JP
- 代理机构： Türk, Dietmar, Dr. rer. nat.
- 优先权： GB4434678 19781114; GB7926705 19790731; GB7937343 19791029
- 主分类号： C12P21/02
- IPC分类号： C12P21/02 ; C07C103/52 ; A61K37/02
摘要：
A lactyl tetrapeptide of the formula
can be prepared by conventional peptide synthesis. One isomer, FR 900156, is obtained by cultivation of a suitable Streptomyces strain such as Str. violaceus ATCC 31481 or Str. olivaceogriseus ATCC 31427.
The invention also relates to a pharmaceutical composition comprising, as an effective ingredient, the above compound in association with a pharmaceutically acceptable, substantially non-toxic carrier or excipient.
can be prepared by conventional peptide synthesis. One isomer, FR 900156, is obtained by cultivation of a suitable Streptomyces strain such as Str. violaceus ATCC 31481 or Str. olivaceogriseus ATCC 31427.
The invention also relates to a pharmaceutical composition comprising, as an effective ingredient, the above compound in association with a pharmaceutically acceptable, substantially non-toxic carrier or excipient.
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