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1.发明授权
公开(公告)号：EP0025842B1
公开(公告)日：1987-06-03
申请号：EP80104502.2
申请日：1980-07-30
发明人： Kitaura, Yoshihiko , Nakaguchi, Osamu , Hemmi, Keiji , Aratani, Matsuhiko , Takeno, Hidekazu , Okada, Satoshi , Tanaka, Hirokazu , Hashimoto, Masashi , Kuroda, Yoshio , Iguchi, Eiko , Kohsaka, Masanobu , Aoki, Hatsuo , Imanaka, Hiroshi
IPC分类号： C07K7/00 , C07H15/04 , C07H15/18 , A61K37/02 , C07C103/50 , C07C125/065
CPC分类号： C07C243/00 , A61K38/00 , C07K5/0215 , C07K9/005 , C12R1/465 , Y02P20/55
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公开(公告)号：EP0044736B1
公开(公告)日：1985-04-24
申请号：EP81303313.1
申请日：1981-07-20
发明人： Imanaka, Hiroshi , Miyoshi, Toshio , Konomi, Toshio , Kubochi, Yoshiaki , Hattori, Seiziro , Kawakita, Takeshi
IPC分类号： C12P35/06
CPC分类号： C12P35/06 , C12N9/18 , Y10S435/911
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3.发明授权
公开(公告)号：EP0015540B1
公开(公告)日：1983-06-22
申请号：EP80101094.3
申请日：1980-03-05
发明人： Yoshida, Keizo , Tanaka, Hirokazu , Okamoto, Masanori , Iguchi, Eiko , Kohsaka, Masanobu , Aoki, Hatsuo , Imanaka, Hiroshi
IPC分类号： C07C119/06 , A61K31/13 , C12P13/00
CPC分类号： C12R1/485 , C07B2200/09 , C07C29/10 , C07C29/147 , C07C29/17 , C07C45/298 , C07D309/12 , C12P13/00 , C12P13/001 , C07C47/21 , C07C33/042 , C07C33/02
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4.发明公开New ribofuranuronic acid derivatives, processes for preparation thereof and pharmaceutical compositions thereof 失效Ribofuranuronsäurederivate，它们的制备方法和含有它们的药物组合物。
公开(公告)号：EP0071926A1
公开(公告)日：1983-02-16
申请号：EP82106942.4
申请日：1982-07-31
发明人： Yamashita, Michio , Komori, Tadaaki , Hosoda, Junji , Kawai, Yoshio , Uchida, Itsuro , Kohsaka, Masanobu , Imanaka, Hiroshi , Sakane, Kazuo , Setoi, Hiroyuki , Teraji, Tsutomu
摘要： New tetrahydrofurancarboxylic acid derivatives of the formula:
wherein
R 1 is amino or a protected amino group,
R 2 is amino or acylamino and
R 3 is carboxy or a protected carboxy group or a pharmaceutically acceptable salt thereof, and processes for their preparation, and also a pharmaceutical composition comprising, as an effective ingredient, the above compound in association with a pharmaceutically acceptable, substantially non-toxic carrier or excipient. The invention also relates to the microorganism Chrysosporium pannormu ATCC 20617 and to starting compounds of the formula
and their preparation.摘要翻译： 式的新四氢呋喃羧酸衍生物：...
... worin ...... [R <1>被氨基或保护的氨基，... - [R <2>是氨基或酰氨基和... - [R <3>是羧基或保护的羧基或 其药学上可接受的盐，以及它们的制备方法，和由此的药物组合物，其包含作为有效的成分，相关联的上述化合物与药学上可接受的，基本上无毒的载体或赋形剂。 因此，本发明涉及微生物金孢子pannormu ATCC 20617和式的起始化合物，... ...和它们的制备。 -
5.发明公开Peptides, process for their preparation, their pharmaceutical compositions and their intermediates 失效肽，其制备方法，其药物组合物和它们的中间体的过程。
公开(公告)号：EP0025842A2
公开(公告)日：1981-04-01
申请号：EP80104502.2
申请日：1980-07-30
发明人： Kitaura, Yoshihiko , Nakaguchi, Osamu , Hemmi, Keiji , Aratani, Matsuhiko , Takeno, Hidekazu , Okada, Satoshi , Tanaka, Hirokazu , Hashimoto, Masashi , Kuroda, Yoshio , Iguchi, Eiko , Kohsaka, Masanobu , Aoki, Hatsuo , Imanaka, Hiroshi
IPC分类号： C07K7/00 , C07H15/04 , C07H15/18 , A61K37/02 , C07C103/50 , C07C125/065
CPC分类号： C07C243/00 , A61K38/00 , C07K5/0215 , C07K9/005 , C12R1/465 , Y02P20/55
摘要： This invention relates to the new peptide of the general formula:
More particularly, this invention relates to this new peptide and the pharmaceutically acceptable salt thereof, which have pharmacological activities, to processesforthe preparation thereof and to a new intermediate for preparing the active peptide, and to the pharmaceutical composition comprising the same and a method of use thereof.摘要翻译： 本发明涉及通式的新的肽：
更具体地说，本发明涉及这种新的肽及其药学上可接受的盐，它们具有药理活性，到其制备方法和用于制备新的中间 活性肽，并且所述药物组合物包含相同和使用它们的方法。 -
6.发明授权FR-900216 substance obtainable by cultivating ATCC 20577 for use as an active therapeutic substance and pharmaceutical antitumor composition comprising FR-900216 substance 失效FR-900216可通过培养ATCC 20577获得的物质作为活性治疗药物和包含FR-900216物质的药物抗微生物组合物
公开(公告)号：EP0132772B1
公开(公告)日：1991-02-27
申请号：EP84108444.5
申请日：1984-07-18
发明人： Kiyoto, Sumio , Okuhara, Masakuni , Kino, Eiko , Tanaka, Hirokazu , Aoki, Hatsuo , Kohsaka, Masanobu , Imanaka, Hiroshi
IPC分类号： C12P1/02 , A61K35/66 , C07D493/22
CPC分类号： C07D493/22 , C12P1/02 , C12R1/845
摘要： FR-900216 substance obtainable by cultivating ATCC 20577 in a nutrient medium containing sources of assimilable carbon and nitrogen under aerobic conditions and recovering it from the culture broth and its use as an active therapeutic substance especially for treatment of tumor. The invention covers also a pharmaceutical antitumor composition comprising FR-900216 substance in association with a pharmaceutically acceptable, substantially non-toxic carrier or excipient.
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7.发明公开FR-900216 substance obtainable by cultivating ATCC 20577 for use as an active therapeutic substance and pharmaceutical antitumor composition comprising FR-900216 substance 失效FR-900216可通过培养ATCC 20577获得的物质作为活性治疗药物和包含FR-900216物质的药物抗肿瘤剂组合物
公开(公告)号：EP0132772A3
公开(公告)日：1987-08-05
申请号：EP84108444
申请日：1984-07-18
发明人： Kiyoto, Sumio , Okuhara, Masakuni , Kino, Eiko , Tanaka, Hirokazu , Aoki, Hatsuo , Kohsaka, Masanobu , Imanaka, Hiroshi
IPC分类号： C12P01/02 , A61K35/66 , C07D493/22 , C12R01/845 , C07D313/00 , C07D309/00 , C07D303/00
CPC分类号： C07D493/22 , C12P1/02 , C12R1/845
摘要： FR-900216 substance obtainable by cultivating ATCC 20577 in a nutrient medium containing sources of assimilable carbon and nitrogen under aerobic conditions and recovering it from the culture broth and its use as an active therapeutic substance especially for treatment of tumor. The invention covers also a pharmaceutical antitumor composition comprising FR-900216 substance in association with a pharmaceutically acceptable, substantially non-toxic carrier or excipient.
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8.发明授权Biologically active WS 6049 substances, a process for the production thereof and their pharmaceutical compositions 失效生物活性WS 6049物质，其生产方法及其药物组合物
公开(公告)号：EP0095154B1
公开(公告)日：1987-01-14
申请号：EP83104988.7
申请日：1983-05-20
发明人： Kiyoto, Sumio , Nishikawa, Motoaki , Iwami, Morita , Terano, Hiroshi , Kohsaka, Masanobu , Imanaka, Hiroshi
CPC分类号： C12R1/03 , C12P1/06 , Y10S435/825
摘要： Biologically active WS 6049 substances obtainable by culturing a strain belonging to the genus Actinomadura in an aqueous nutrient medium under aerobic conditions and recovering WS 6049-A substance and/or WS 6049-B substance. The invention also relates to a process for preparing the new substances and pharmaceutical compositions comprising such substances as an active ingredient together with a non-toxic, pharmaceutically acceptable carrier.
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9.发明公开N-acyl peptide, processes for their preparation and pharmaceutical compostions thereof 失效N-乙酰基肽，其制备方法及其药物组合物
公开(公告)号：EP0085255A3
公开(公告)日：1984-08-01
申请号：EP82306928
申请日：1982-12-23
发明人： Umehara, Kazuyoshi , Yoshida, Keizo , Tanaka, Hirokazu , Uchida, Itsuo , Kohsaka, Masanobu , Imanaka, Hiroshi
IPC分类号： C07C103/52 , A61K37/02
CPC分类号： C07K5/06104 , A61K38/00 , C07K5/06052 , C07K5/06078 , C07K5/06086
摘要： Compounds of the formula:
wherein
R 1 is hydrogen, alkanoyloxy or alkenoyloxy; R 2 is alkyl or alkenyl; R 3 and R 4 are each hydrogen, lower alkyl, hydroxy(lower)alkyl, ar(lower) alkyl, esterified carboxy(lower)alkyl, carboxy-(lower)alkyl, protected amino(lower)alkyl or amino(lower)alkyl; R 5 is hydrogen, hydroxy(lower)alkyl, protected amino-(lower)alkyl, amino(lower)alkyl, carboxy(lower)alkyl or esterified carboxy(lower)alkyl; R 6 is carboxy, esterifed carboxy or sulfo(lower)alkyl; A 1 , A 2 and A3 are each bond or lower alkylene; and m and n are each an integer of 0 or 1; and their pharmaceutically- acceptable salts have anti-complementary activity and fibrinolytic activity, and are useful as therapeutic agents for immunecomplex diseases or autoimmune diseases such as nephritis, rheumatic diseases, systemic lupus erythematosus, etc. and thrombosis such as cerebral apoplexy, coronary insufficiency, pulmonary embolism.-
10.发明公开New furanone derivatives, process for the preparation thereof and use thereof 失效Furanonderivate，Verfahren zu ihrer Herstellung und ihre Verwendung。
公开(公告)号：EP0099692A1
公开(公告)日：1984-02-01
申请号：EP83303877.1
申请日：1983-07-04
IPC分类号： C07D307/32 , C07D307/58 , C07D307/60 , A61K31/365 , C12P17/04 , C12N1/14
CPC分类号： C07D303/22 , C07C43/166 , C07D307/33 , C07D307/58 , C07D307/60 , C07D309/12 , C12P17/04 , C12R1/645 , Y02P20/55
摘要： The present invention provides compounds of the formula:-
wherein A is a lower alkylene group; R' is a carboxy, hydroxy, protected hydroxy, lower alkoxycarbonyl, lower alkoxycarbonylamino or lower alkanoyloxy group; R 2 is a hydrogen or halogen atom or a halo (lower) - alkyl group; R 3 is a hydrogen or halogen atom; R 4 is a hydrogen atom or a hydroxy, carboxy, lower alkoxy, lower alkanoyloxy or lower alkoxycarbonyloxy group and R 5 is a hydrogen or halogen atom or R 4 and R 5 together represent the group =CH 2 ; F is the number of double bonds which is equal to 0 or 1 and n is an integer of 0 or 1, with the proviso that when F is 0 then n is 1 and when F is 1 then n is 0; and the pharmaceutically- acceptable salts thereof.
The present invention also provides processes for the preparation of these compounds and pharmaceutical compositions containing them. Futhermore, the present invention is concerned with the use of these compounds for the treatment of diabetic cataract and/or neuropathy.摘要翻译： 本发明提供下式的化合物：其中A为低级亚烷基; R 1是羧基，羟基，保护的羟基，低级烷氧基羰基，低级烷氧基羰基氨基或低级烷酰氧基; R 2是氢或卤素原子或卤代（低级） - 烷基; R 3是氢或卤素原子; R 4是氢原子或羟基，羧基，低级烷氧基，低级烷酰氧基或低级烷氧基羰氧基，R 5是氢或卤素原子，或者R 4和R 5一起代表基团= CH 2 ; F是等于0或1的双键数，n是0或1的整数，条件是当F为0时，n为1，当F为1时，n为0; 及其药学上可接受的盐。 本发明还提供了制备这些化合物的方法和含有它们的药物组合物。 此外，本发明涉及这些化合物用于治疗糖尿病性白内障和/或神经病变的用途。
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