发明公开
EP0105361A4 ANTAGONISM OF CENTRAL NERVOUS SYSTEM DRUGS BY THE ADMINISTRATION OF 4-AMINOPYRIDINE ALONE OR IN COMBINATION WITH OTHER DRUGS.
失效
ANTAGONISMUS VON HEILMITTELN DES ZENTRALNERVENSYSTEMS DURCH VERABREICHEN DES 4-AMINOPYRIDINS ALLEIN ODER IN ZUSAMMENHANG MIT SONSTIGEN HEILMITTELN。
- 专利标题： ANTAGONISM OF CENTRAL NERVOUS SYSTEM DRUGS BY THE ADMINISTRATION OF 4-AMINOPYRIDINE ALONE OR IN COMBINATION WITH OTHER DRUGS.
- 专利标题（中）： ANTAGONISMUS VON HEILMITTELN DES ZENTRALNERVENSYSTEMS DURCH VERABREICHEN DES 4-AMINOPYRIDINS ALLEIN ODER IN ZUSAMMENHANG MIT SONSTIGEN HEILMITTELN。
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申请号： EP83901675申请日： 1983-04-13
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公开(公告)号： EP0105361A4公开(公告)日： 1984-07-24
- 发明人: BOOTH NICHOLAS H , HATCH ROGER C , CRAWFORD LESTER M
- 申请人： UNIV GEORGIA RES FOUND
- 专利权人： UNIV GEORGIA RES FOUND
- 当前专利权人： UNIV GEORGIA RES FOUND
- 优先权： US36786482 1982-04-13
- 主分类号： C07D489/00
- IPC分类号： C07D489/00 ; A61K31/44 ; A61K31/4409 ; A61K31/445 ; A61K31/475 ; A61K31/485 ; C07D213/00 ; C07D459/00
摘要：
The use of 4-aminopyridine and congeners or derivatives thereof to antagonize drugs which act at or upon central nervous system receptors, especially dopamine receptors, such as butyrophenones and congeners or derivatives thereof. 4-aminopyridine is used above or in combination with other drugs such as naloxone hydrochloride or yohimbine hydrochloride. The use of 4-aminopyridine overcomes the problems of drug overdoses of drugs which act at or upon central nervous system receptors, especially dopamine receptors by reversing the effects of toxic amounts or toxic dosages.
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