-
1.发明公开PYRIDINONE DIKETO ACIDS: INHIBITORS OF HIV REPLICATION IN COMBINATION THERAPY 审中-公开吡啶酮二酮酸：联合治疗中HIV复制的抑制剂
公开(公告)号：EP2046328A4
公开(公告)日：2009-10-28
申请号：EP07810432
申请日：2007-07-13
发明人： NAIR VASU , SEO BYUNG I , UCHIL VINOD R , CHI GUOCHEN
IPC分类号： A61K31/4412 , A61P31/18 , C07D211/86
CPC分类号： C07D213/64 , C07D213/68
-
公开(公告)号：EP1579037A4
公开(公告)日：2008-02-13
申请号：EP03711399
申请日：2003-03-03
发明人： HUNG YEN-CON , CHUNG DONGHWAN
CPC分类号： A61L2/035 , A61L2/18 , C02F1/4618 , C02F1/4674 , C02F2001/46142 , C02F2201/46115 , C02F2201/46145 , C02F2201/46185 , C02F2209/04 , C02F2209/06 , C02F2303/04
摘要： Feed water comprising an aqueous salt solution is supplied to an anode chamber (12) and to a cathode chamber (14). The feed water is cathodically electrolyzed in the cathode chamber (14) to produce alkaline electrolyzed water (catholyte) and is anodically electrolyzed in the anode chamber (12) to produce electrolyzed water (anolyte) whose pH is modified. A portion of alkaline catholyte from the cathode chamber (14) is recycled back to the feed water during continuous electrolysis to provide a blend of feed water and alkaline catholyte to the anode chamber (12) to control pH of the anodically electrolyzed water therein to provide more stable bactericidal activity thereof over time.
-
公开(公告)号：EP1742656A4
公开(公告)日：2007-11-14
申请号：EP05733210
申请日：2005-03-14
CPC分类号： A61K39/012 , A61K2039/55511
-
公开(公告)号：EP1592773A4
公开(公告)日：2007-08-15
申请号：EP04704892
申请日：2004-01-23
发明人： IVARIE ROBERT D , HARVEY ALEX J , MORRIS JULIE A , LIU GUODONG , RAPP JEFFREY C
IPC分类号： C12N15/85 , C12N15/867 , C12N15/90 , A01K67/00 , A01K67/027 , C12N15/00
CPC分类号： C12N15/86 , A01K2217/05 , A01K2227/30 , A01K2267/01 , C12N15/8509 , C12N15/902 , C12N2740/13043 , C12N2799/027 , C12N2830/008 , C12N2830/15 , C12N2830/40 , C12N2830/90 , C12N2840/20 , C12N2840/203
摘要： This invention provides vectors and methods for the stable introduction of exogenous nucleic acid sequences into the genome of avians in order to express the exogenous sequences to alter the phenotype of the avians or to produce desired proteins. In particular, transgenic avians are produced which express exogenous sequences in their oviducts and which deposit exogenous proteins into their eggs. Avian eggs that contain exogenous proteins are encompassed by this invention. The instant invention further provides novel forms of interferon and erythropoietin which are efficiently expressed in the oviduct of transgenic avians and deposited into avian eggs.
-
公开(公告)号：EP1478322A4
公开(公告)日：2007-08-08
申请号：EP02756310
申请日：2002-06-24
发明人： CHU CHUNG K , OTTO MICHAEL J , SHI JUNXING , SCHINAZI RAYMOND F , CHOI YONGSEOK , GUMINA GIUSEPPE , CHONG YOUHOON , STUYVER LIEVEN J
IPC分类号： A01N43/04 , A61K31/52 , A61K31/522 , A61K31/675 , A61K31/70 , A61K31/7064 , A61K31/7068 , A61K31/7076 , A61K45/00 , A61P31/14 , A61P31/18 , A61P35/00 , C07H9/04 , C07H19/06 , C07H19/16
CPC分类号： A61K31/70 , A61K31/52 , A61K31/522 , A61K31/675 , C07H9/04 , C07H19/06
摘要： The present invention includes compounds and compositions of β-halonucleosides, as well as methods to treat HIV, HBV or abnormal cellular proliferation comprising administering said compounds or compositions.
摘要翻译： 本发明包括β-卤代核苷的化合物和组合物，以及治疗HIV，HBV或异常细胞增殖的方法，包括施用所述化合物或组合物。
-
公开(公告)号：EP1689858A4
公开(公告)日：2007-07-11
申请号：EP04810564
申请日：2004-11-08
发明人： BROWN THOMAS PAUL
IPC分类号： C07K14/08 , A61K39/12 , C07H21/04 , C12N20060101 , C12N7/00 , C12Q1/70 , G01N33/48 , G01N33/50 , G01N33/569 , G06F19/00
CPC分类号： C12N7/00 , A61K2039/5252 , A61K2039/5254 , C07K14/005 , C12N2720/10021 , C12N2720/10022 , C12Q1/701 , G01N33/5082 , G01N33/56983 , G06F19/22
摘要： Characterization of infectious bursal disease virus (“IBDV”) for use in vaccine identification and production that provides rapid selection of a specific vaccine strain with an IBDV sequence most related to the IBDV of interest or identification of a novel strain of IBDV.
-
7.发明公开AVIAN TRANSGENESIS USING A CHICKEN OVALBUMIN GENE REGION 审中-公开VOGELTRANSGENESE UNTER VERWENDUNG EINESHÜHNEREIALBUMIN-GENBEREICHS
公开(公告)号：EP1623035A4
公开(公告)日：2006-08-30
申请号：EP03816706
申请日：2003-12-11
CPC分类号： C12N15/8509 , A01K67/0278 , A01K2217/05 , A01K2217/072 , A01K2227/30 , A01K2267/01 , C07K16/00 , C07K2317/11 , C07K2317/21 , C12N2799/02 , C12N2800/10 , C12N2800/204 , C12N2800/206 , C12N2830/90
摘要： The present invention provides isolated and recombinant avian nucleic acid molecules comprising at least one avian MAR and an avian nucleic acid sequence encoding an ovalbumin transcriptional regulatory region. The isolated nucleic acid of the present invention is useful for reducing chromosomal positional effects upon the transcription of a transgene operably linked to the ovalbumin transcriptional regulatory region and transfected into a recipient avian cell The recombinant nucleic cid molecules of the present invention may further comprise a polyadenylation signal sequence or an avian 3' domain, and optionally, an internal ribosome entry site for expression of an operably linked heterologous nucleic acid insert in a transfected avian cell.
摘要翻译： 本发明提供了分离的和重组的禽核酸分子，其包含至少一个禽MAR和编码卵清蛋白转录调节区的禽核酸序列。 本发明的分离的核酸可用于降低染色体位置效应，所述染色体位置效应对与卵清蛋白转录调控区有效连接的转基因进行转录并转染至受体禽类细胞中。本发明的重组核酸分子可进一步包含聚腺苷酸化 信号序列或禽类3'结构域，并且任选地，用于在转染的禽细胞中表达可操作地连接的异源核酸插入物的内部核糖体进入位点。
-
公开(公告)号：EP1570047A4
公开(公告)日：2006-03-29
申请号：EP03789980
申请日：2003-11-24
发明人： DOYLE MICHAEL P , ZHAO TONG
CPC分类号： A01N63/00 , A23L3/3463 , C12N1/20 , C12N11/02 , C12Q1/18 , C12R1/225 , C12R1/46 , Y10S435/821 , Y10S435/822 , A01N2300/00
摘要： A composition and method for the inhibition of microorganisms.
-
公开(公告)号：EP1379634A4
公开(公告)日：2004-09-08
申请号：EP02728885
申请日：2002-04-22
发明人： BAIG SALMAN
IPC分类号： G01N33/53 , C12N9/50 , C12N9/99 , G01N24/08 , G01N33/573 , C12Q1/34 , C12Q1/37 , C12Q1/42 , C12Q1/44
摘要： A method for identifying active site inhibitors of scission enzyme that cleaves the backbones or side groups of peptides, and for using the resultant inactivators to inhibit the target scission enzyme. Kinetic assays are employed to identify peptide substrates that tightly bind to the active site of the target protease but that are not easily cleaved. These noncleavable but tightly binding substrates are optionally structurally modified to yield inhibitory compounds with optimized properties. Additionally these substrates exhibit apparent specificity for a transition state or ground state configuration of the protease.
-
公开(公告)号：EP0954223A4
公开(公告)日：2002-01-16
申请号：EP97928703
申请日：1997-06-04
发明人： RITCHIE BRANSON W , LUKERT PHIL D , PESTI DENISE
IPC分类号： A61K39/12 , A01N63/00 , A61K45/00 , A61K45/05 , B29D31/00 , C12N7/00 , C12N7/01 , C12N7/04 , C12N7/06 , C12N7/08
CPC分类号： A61K39/12 , A61K2039/5254 , A61K2039/552 , C12N2710/22034 , Y10S424/816
摘要： The present invention provides a vaccine which is protective against avian polyomavirus infection in a bird which is classified as being a member of the Psittaciformes order which comprises an immunogenic amount of a modified live avian polyomavirus in a pharmaceutically acceptable carrier. Methods are also provided for preventing avian polyomavirus infection in a bird, or in several different species of birds, classified as being a member of the Psittaciformes order, comprising administering a vaccine comprising an immunogenic amount of a modified live avian polyomavirus and a pharmaceutically acceptable carrier. A preferred embodiment provides a modified live avian polyomavirus vaccine for prevention of wild-type infection in a Budgerigar, lovebird or Cockatiel.
-
-
-
-
-
-
-
-
-
搜索结果
62 条记录 (耗时 0.019 秒)
