发明公开
- 专利标题： Therapeutic and prophylactic agents for peptic ulcer, compounds contained therein and processes for their production
- 专利标题（中）： 用于胶囊的治疗剂和预防剂，含有化合物及其生产方法
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申请号： EP86106993申请日： 1986-05-23
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公开(公告)号： EP0203541A3公开(公告)日： 1987-03-18
- 发明人: Shiraga, Yusei , Fukaya, Chikara , Akira, Toshiaki , Iwai, Masakazu , Yokoyama, Kazumasa , Tabata, Mamoru , Fukui, Hiroshi , Tanaka, Shigeo , Iga, Yoshiro , Suyama, Tadakazu , Okano, Kanemichi
- 申请人： GREEN CROSS CORPORATION
- 专利权人： GREEN CROSS CORPORATION
- 当前专利权人： GREEN CROSS CORPORATION
- 优先权： JP11283685 19850525; JP11283785 19850525; JP11283885 19850525; JP23473985 19851021
- 主分类号： C07C49/647
- IPC分类号： C07C49/647 ; C07C45/65 ; C07C49/242 ; C07C49/255 ; A61K31/12 ; C07C43/23 ; C07C43/20
摘要：
A therapeutic and prophylactic agent for peptic ulcers which contains as an active ingredient a compound of the general formula (I):
wherein R, represents hydrogen or =0; R 2 represents hydrogen or-OR 5 ; R 3 represents hydrogen or-OR 6 ; R 4 represents -OR 7 in the case of the absence of double bond, R 5 , R 6 and R 7 each represents hydrogen or an organic residue;
X represents group (A):
or group (B):
wherein R 8 represents alkyl, and R 9 and R 10 each represents hydrogen or an organic residue; with the proviso that when X represents group (A), then R, and R 3 both represent hydrogen, R 2 represents -OR 5 , R 4 represents -OR 7 and the bond between the carbon atom to which X is attached and the carbon atom to which R 4 is attached is a single bond, and when X represents group (B), then R 1 represents =0, R 2 and R 4 both represent hydrogen, R 3 represents-OR 6 and the bond between the carbon atom to which X is attached and the carbon atom to which R 4 is attached is a double bond, or a pharmaceutically acceptable salt thereof, or a compound of the general formula (II):
wherein R 11 represents hydrogen or an organic residue, and R 12 , R 13 and R 14 each represents an organic residue, or a pharmaceutically acceptable salt thereof. The compounds of the general formulae (I) and (II) can be derived from compounds contained in a hot water extract of cinnamon.
wherein R, represents hydrogen or =0; R 2 represents hydrogen or-OR 5 ; R 3 represents hydrogen or-OR 6 ; R 4 represents -OR 7 in the case of the absence of double bond, R 5 , R 6 and R 7 each represents hydrogen or an organic residue;
X represents group (A):
or group (B):
wherein R 8 represents alkyl, and R 9 and R 10 each represents hydrogen or an organic residue; with the proviso that when X represents group (A), then R, and R 3 both represent hydrogen, R 2 represents -OR 5 , R 4 represents -OR 7 and the bond between the carbon atom to which X is attached and the carbon atom to which R 4 is attached is a single bond, and when X represents group (B), then R 1 represents =0, R 2 and R 4 both represent hydrogen, R 3 represents-OR 6 and the bond between the carbon atom to which X is attached and the carbon atom to which R 4 is attached is a double bond, or a pharmaceutically acceptable salt thereof, or a compound of the general formula (II):
wherein R 11 represents hydrogen or an organic residue, and R 12 , R 13 and R 14 each represents an organic residue, or a pharmaceutically acceptable salt thereof. The compounds of the general formulae (I) and (II) can be derived from compounds contained in a hot water extract of cinnamon.
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