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    Therapeutic and prophylactic agents for peptic ulcer, compounds contained therein and processes for their production
    2.
    发明公开
    Therapeutic and prophylactic agents for peptic ulcer, compounds contained therein and processes for their production 失效
    治疗和预防剂用于治疗消化性溃疡，所述化合物包含在其中的和它们的制备方法。

    公开(公告)号：EP0203541A2

    公开(公告)日：1986-12-03

    申请号：EP86106993.8

    申请日：1986-05-23

    申请人： GREEN CROSS CORPORATION

    发明人： Shiraga, Yusei ,  Fukaya, Chikara ,  Akira, Toshiaki ,  Iwai, Masakazu ,  Yokoyama, Kazumasa ,  Tabata, Mamoru ,  Fukui, Hiroshi ,  Tanaka, Shigeo ,  Iga, Yoshiro ,  Suyama, Tadakazu ,  Okano, Kanemichi

    IPC分类号： C07C49/647 ,  C07C45/65 ,  C07C49/242 ,  C07C49/255 ,  A61K31/12 ,  C07C43/23 ,  C07C43/20

    CPC分类号： C07C403/08 ,  C07C403/10 ,  C07C403/12 ,  C07C2601/16 ,  C07H15/18 ,  C07H15/203 ,  Y10S514/927

    摘要： A therapeutic and prophylactic agent for peptic ulcers which contains as an active ingredient a compound of the general formula (I):
    wherein R, represents hydrogen or =0; R 2 represents hydrogen or-OR 5 ; R 3 represents hydrogen or-OR 6 ; R 4 represents -OR 7 in the case of the absence of double bond, R 5 , R 6 and R 7 each represents hydrogen or an organic residue;
    X represents group (A):
    or group (B):
    wherein R 8 represents alkyl, and R 9 and R 10 each represents hydrogen or an organic residue; with the proviso that when X represents group (A), then R, and R 3 both represent hydrogen, R 2 represents -OR 5 , R 4 represents -OR 7 and the bond between the carbon atom to which X is attached and the carbon atom to which R 4 is attached is a single bond, and when X represents group (B), then R 1 represents =0, R 2 and R 4 both represent hydrogen, R 3 represents-OR 6 and the bond between the carbon atom to which X is attached and the carbon atom to which R 4 is attached is a double bond, or a pharmaceutically acceptable salt thereof, or a compound of the general formula (II):
    wherein R 11 represents hydrogen or an organic residue, and R 12 , R 13 and R 14 each represents an organic residue, or a pharmaceutically acceptable salt thereof. The compounds of the general formulae (I) and (II) can be derived from compounds contained in a hot water extract of cinnamon.

    摘要翻译： 用于治疗消化性溃疡的治疗和预防剂，其含有通式（I）的化合物作为活性成分：（I）worin R1 darstellt氢或= O; R2 darstellt氢或-OR 5; R3 darstellt氢或-OR 6; R4 darstellt -OR7在不存在双键的情况下; R5，R6和R7各自darstellt氢或有机残基; X darstellt组（A）：= C = CH-COR8（A）或（B）组：（B）worin R8 darstellt烷基，和R9和R10各自darstellt氢或有机残基; 其条件做当X darstellt组（A）然后，氢R1和R3同时代表，R2 darstellt -OR 5; R4 darstellt OR7和的碳原子，其中X是连接和其中R 4连接的碳原子之间的键是单键，并且当X darstellt组（B），则R1 darstellt = O，R2 darstellt氢，R3 darstellt -OR 6和的碳原子，其中X是连接和其中R 4连接的碳原子之间的键是双键，或其药学上可接受的盐，或通式（II）的化合物：（ II）worin R11 darstellt氢或有机残基，并且R12，R13和R14各自darstellt到有机残基，或其药学上可接受的盐。 通式饮食（I）和（II）可从包含在肉桂的热水提取物的化合物衍生的化合物。

    Method of heat-treating plasma proteins
    4.
    发明公开
    Method of heat-treating plasma proteins 失效
    Verfahren zurWärmebehandlungvon Plasmaproteinen。

    公开(公告)号：EP0142059A2

    公开(公告)日：1985-05-22

    申请号：EP84112515.6

    申请日：1984-10-17

    申请人： GREEN CROSS CORPORATION

    发明人： Iga, Yoshiro ,  Okano, Kanemichi ,  Akira, Toshiaki ,  Kameyama, Shoju

    IPC分类号： A61L2/04

    CPC分类号： A61L2/0023 ,  A61K31/14 ,  A61K35/14 ,  A61K38/48 ,  A61L2/04

    摘要： The invention relates to a method of heat-treating heat-labile plasma proteins for virus inactivation comprising heating a virus-contaminated plasma protein in a dry state and in the presence of both an acidic amino acid and a basic amino acid until virus inactivation is complete.

    摘要翻译： 本发明涉及一种用于病毒灭活的热不稳定血浆蛋白的热处理方法，其包括在干燥状态下和在酸性氨基酸和碱性氨基酸存在下加热病毒污染的血浆蛋白，直到病毒灭活完成。

    Method of purifying factor VIII
    6.
    发明公开
    Method of purifying factor VIII 失效
    Verfahren zur Reinigung von Faktor-VIII。

    公开(公告)号：EP0245875A2

    公开(公告)日：1987-11-19

    申请号：EP87107083.5

    申请日：1987-05-15

    申请人： GREEN CROSS CORPORATION

    发明人： Kameyama, Syojyu ,  Nishimaki, Hideo ,  Iga, Yoshiro ,  Suyama, Tadakazu

    IPC分类号： C07K3/18

    CPC分类号： C07K14/755 ,  A61K38/00 ,  H01R13/5205

    摘要： A method for purifying factor VIII complex comprising: (A) adsorbing an impure extract containing factor VIII complex on a water-insoluble carrier, and (B) recovering factor VIII complex in the unadsorbed frac­tions, wherein said water-insoluble carrier contains as a ligand a group represented by the formula (I) or (II):
    (CH₂) n -NH₂ (I) or
    (CH₂) n -CHO (II)
    wherein n is an integer of from 3 to 10.

    摘要翻译： 一种净化因子VIII复合物的方法，包括：（A）在水不溶性载体上吸附含有因子VIII复合物的不纯提取物，和（B）回收未吸附级分中的VIII族配合物，其中所述水不溶性载体含有配体 由式（I）或（II）表示的基团：（CH 2）n -NH 2（I）或（CH 2）n CHO（II）其中n为3至10的整数。