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    Therapeutic and prophylactic agents for peptic ulcer, compounds contained therein and processes for their production
    1.
    发明公开
    Therapeutic and prophylactic agents for peptic ulcer, compounds contained therein and processes for their production 失效
    治疗和预防剂用于治疗消化性溃疡，所述化合物包含在其中的和它们的制备方法。

    公开(公告)号：EP0203541A2

    公开(公告)日：1986-12-03

    申请号：EP86106993.8

    申请日：1986-05-23

    申请人： GREEN CROSS CORPORATION

    发明人： Shiraga, Yusei ,  Fukaya, Chikara ,  Akira, Toshiaki ,  Iwai, Masakazu ,  Yokoyama, Kazumasa ,  Tabata, Mamoru ,  Fukui, Hiroshi ,  Tanaka, Shigeo ,  Iga, Yoshiro ,  Suyama, Tadakazu ,  Okano, Kanemichi

    IPC分类号： C07C49/647 ,  C07C45/65 ,  C07C49/242 ,  C07C49/255 ,  A61K31/12 ,  C07C43/23 ,  C07C43/20

    CPC分类号： C07C403/08 ,  C07C403/10 ,  C07C403/12 ,  C07C2601/16 ,  C07H15/18 ,  C07H15/203 ,  Y10S514/927

    摘要： A therapeutic and prophylactic agent for peptic ulcers which contains as an active ingredient a compound of the general formula (I):
    wherein R, represents hydrogen or =0; R 2 represents hydrogen or-OR 5 ; R 3 represents hydrogen or-OR 6 ; R 4 represents -OR 7 in the case of the absence of double bond, R 5 , R 6 and R 7 each represents hydrogen or an organic residue;
    X represents group (A):
    or group (B):
    wherein R 8 represents alkyl, and R 9 and R 10 each represents hydrogen or an organic residue; with the proviso that when X represents group (A), then R, and R 3 both represent hydrogen, R 2 represents -OR 5 , R 4 represents -OR 7 and the bond between the carbon atom to which X is attached and the carbon atom to which R 4 is attached is a single bond, and when X represents group (B), then R 1 represents =0, R 2 and R 4 both represent hydrogen, R 3 represents-OR 6 and the bond between the carbon atom to which X is attached and the carbon atom to which R 4 is attached is a double bond, or a pharmaceutically acceptable salt thereof, or a compound of the general formula (II):
    wherein R 11 represents hydrogen or an organic residue, and R 12 , R 13 and R 14 each represents an organic residue, or a pharmaceutically acceptable salt thereof. The compounds of the general formulae (I) and (II) can be derived from compounds contained in a hot water extract of cinnamon.

    摘要翻译： 用于治疗消化性溃疡的治疗和预防剂，其含有通式（I）的化合物作为活性成分：（I）worin R1 darstellt氢或= O; R2 darstellt氢或-OR 5; R3 darstellt氢或-OR 6; R4 darstellt -OR7在不存在双键的情况下; R5，R6和R7各自darstellt氢或有机残基; X darstellt组（A）：= C = CH-COR8（A）或（B）组：（B）worin R8 darstellt烷基，和R9和R10各自darstellt氢或有机残基; 其条件做当X darstellt组（A）然后，氢R1和R3同时代表，R2 darstellt -OR 5; R4 darstellt OR7和的碳原子，其中X是连接和其中R 4连接的碳原子之间的键是单键，并且当X darstellt组（B），则R1 darstellt = O，R2 darstellt氢，R3 darstellt -OR 6和的碳原子，其中X是连接和其中R 4连接的碳原子之间的键是双键，或其药学上可接受的盐，或通式（II）的化合物：（ II）worin R11 darstellt氢或有机残基，并且R12，R13和R14各自darstellt到有机残基，或其药学上可接受的盐。 通式饮食（I）和（II）可从包含在肉桂的热水提取物的化合物衍生的化合物。

    Therapeutic and prophylactic agents for peptic ulcer, compounds contained therein and processes for their production
    3.
    发明公开
    Therapeutic and prophylactic agents for peptic ulcer, compounds contained therein and processes for their production 失效
    用于胶囊的治疗剂和预防剂，含有化合物及其生产方法

    公开(公告)号：EP0203541A3

    公开(公告)日：1987-03-18

    申请号：EP86106993

    申请日：1986-05-23

    申请人： GREEN CROSS CORPORATION

    发明人： Shiraga, Yusei ,  Fukaya, Chikara ,  Akira, Toshiaki ,  Iwai, Masakazu ,  Yokoyama, Kazumasa ,  Tabata, Mamoru ,  Fukui, Hiroshi ,  Tanaka, Shigeo ,  Iga, Yoshiro ,  Suyama, Tadakazu ,  Okano, Kanemichi

    IPC分类号： C07C49/647 ,  C07C45/65 ,  C07C49/242 ,  C07C49/255 ,  A61K31/12 ,  C07C43/23 ,  C07C43/20

    CPC分类号： C07C403/08 ,  C07C403/10 ,  C07C403/12 ,  C07C2601/16 ,  C07H15/18 ,  C07H15/203 ,  Y10S514/927

    摘要： A therapeutic and prophylactic agent for peptic ulcers which contains as an active ingredient a compound of the general formula (I):
    wherein R, represents hydrogen or =0; R 2 represents hydrogen or-OR 5 ; R 3 represents hydrogen or-OR 6 ; R 4 represents -OR 7 in the case of the absence of double bond, R 5 , R 6 and R 7 each represents hydrogen or an organic residue;
    X represents group (A):
    or group (B):
    wherein R 8 represents alkyl, and R 9 and R 10 each represents hydrogen or an organic residue; with the proviso that when X represents group (A), then R, and R 3 both represent hydrogen, R 2 represents -OR 5 , R 4 represents -OR 7 and the bond between the carbon atom to which X is attached and the carbon atom to which R 4 is attached is a single bond, and when X represents group (B), then R 1 represents =0, R 2 and R 4 both represent hydrogen, R 3 represents-OR 6 and the bond between the carbon atom to which X is attached and the carbon atom to which R 4 is attached is a double bond, or a pharmaceutically acceptable salt thereof, or a compound of the general formula (II):
    wherein R 11 represents hydrogen or an organic residue, and R 12 , R 13 and R 14 each represents an organic residue, or a pharmaceutically acceptable salt thereof. The compounds of the general formulae (I) and (II) can be derived from compounds contained in a hot water extract of cinnamon.

    摘要翻译： 含有作为活性成分的通式（I）的化合物的消化性溃疡的治疗和预防剂：其中R1表示氢或= O; R2代表氢或-OR5; R3表示氢或-OR6; 在不存在双键的情况下，R 4表示-OR 7; R5，R6和R7各自表示氢或有机残基; X表示基团（A）：= C = CH-COR 8（A）或基团（B）：其中R 8表示烷基，R 9和R 10各自表示氢或有机残基; 条件是当X表示基团（A）时，则R 1和R 3都表示氢，R 2表示-OR 5; R4表示OR7，X所连接的碳原子和与R4连接的碳原子之间的键为单键，当X表示基团（B）时，R 1表示= O，R 2表示氢，R 3表示 -OR 6，X所连接的碳原子和R 4连接的碳原子之间的键是双键，或其药学上可接受的盐，或通式（II）的化合物： II）其中R11表示氢或有机残基，R12，R13和R14各自表示有机残基或其药学上可接受的盐。 通式（I）和（II）的化合物可以衍生自肉桂热水提取物中所含的化合物。